HPL、SP_1在妊娠晚期监测胎盘功能的意义被引量：1

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摘要目的:探讨孕妇妊娠晚期血清人胎盘泌乳素(HPL)和妊娠特异性β1糖蛋白(SP1)与各种妊娠并发症和不良妊娠结局的关系,以推测这两种激素在监测胎盘功能中的意义。方法:应用放射免疫法对167例孕妇血清HPL和SP1进行测定,并对孕晚期异常情况进行观察。结果:重度妊娠高血压综合征(妊高征)、重度妊高征合并胎儿宫内发育迟缓、低体重儿组HPL、SP1低值;轻、中度妊高征、羊水过少、妊娠期糖尿病组HPL、SP1与正常妊娠对照组相比无明显差异(P>0.05);巨大儿组HPL、SP1值高于正常妊娠对照组。结论:HPL、SP1在妊娠晚期的下降可能提示胎盘功能低下。

作者吴月莲马刚周焕锦黄星

机构地区广西壮族自治区人民医院妇产科广西医科大学第一附属医院妇产科

出处《广西医科大学学报》 CAS 北大核心 2008年第6期899-901,共3页 Journal of Guangxi Medical University

关键词人胎盘泌乳素妊娠特异性Β1糖蛋白胎盘功能妊娠结局

分类号 R714 [医药卫生—妇产科学]

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参考文献5

1曹泽毅.中华妇产科学[M].北京：人民卫生出版社,2000.221-272.
2乐杰.妇产科学[M].北京：人民卫生出版社,2001.104.
3杨康.胎盘泌乳素.国外医学：内分泌学分册,1984,6(1):19-20.
4Handwerger S, Freemark M. The roles of placental growth hormone and placental lactogen in the regulation of human fetal growth and development [J].J Pediatr Endocrinol Metab, 2000,13 (4) : 343-356.
5唐小云,鞠宝玲,宋宝辉.妊娠特异性糖蛋白免疫抑制作用的研究[J].中国优生与遗传杂志,2008,16(6):33-35. 被引量：3

二级参考文献12

1Bohn H. Detection and characterization of pregnancy proteins in the human placenta and their quantitative immunochemical determination in sera from pregnant women [ J ]. Arch Gynakol, 1971,210 ( 4 ) :440 - 457.
2Mezzesimi A, Florio P, Reis FM, et al. The detection of anti -beta2 - glycoprotein I antibodies is associated with increased risk of pregnancy loss in women with threatened abortion in the first trimester [ J ]. Eur J Obstet Gynecol Reprod Biol,2007,133 (2) : 164 - 168.
3Gardner MO, Goldenberg RL, Cliver SP,et al. Maternal serum concentrations of human placental lactogen, estradiol and pregnancy specific beta 1 -glycoprotein and fetal growth retardation [ J ]. Acta Obstet Gynecol Scand Suppl, 1997,165:56 - 8.
4Okazaki S, Sekizawa A, Purwosunu Y, et al. Placenta - derived, cellular messenger RNA expression in the maternal blood of preeelamptic women [ J ]. Obstet Gynecol,2007,110 ( 5 ) : 1130 - 1136.
5Motran CC, Diaz FL, Montes CL, et al. In vivo expression of recombinant pregnant - specfic glycoprotein la induces alternative activation of monocytes and enhances Th2 -type immune response[J]. Eur J Immunol,2003,33 ( 11 ) :3007 - 3016.
6Motran CC, Diaz FL, Gruppi A, et al. Human pregnancy- specific glycopretein 1a (PSG1a) induces alternative activation in human and mouse monocytes and suppresses the accessory cell - dependent T cell proliferation[J]. J Leukoc Biol,2002,72(3) :512 -521.
7Wynne F, Ball M, McLellan AS, et al. Mouse pregnancy- specific glycoproteins: tissue-specific expression and evidence of association with maternal vasculature [ J ]. Reproduction, 2006, 131 (4) : 721 - 732.
8Tan SL, Zhao J, Bi C, et al. Resistance to experimental autoimmune encephalomyelitis and impaired IL - 17 production in protein kinase C theta - dificient mice [ J ]. J Immunol,2006,176 ( 5 ) :2872 - 2879.
9Sacchetti B, Bielavska E. Chelerythrine, a specific PKC inhibitor, blocks acquisition but not consolidation and retrieval of conditioned taste aversion in rat[J]. Brain Res,1998,799( 1 ) :84-94.
10Cohen - Saidon C, Razin E. The involvement of Bcl - 2 in mast cell apoptosis [ J ]. Novartis Found Syrup, 2005,271 : 191 - 195.