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帕金森病运动并发症的研究进展 被引量:3

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摘要 帕金森病(Parkinson’s disease,PD)是一种常见的慢性进展性神经系统变性疾病,以其在中老年人群中的高发病率和致残率及沉重的经济负担而备受关注。自1967年Cotzias等将左旋多巴(L-dopa)首次成功应用于临床后,PD患者的命运从此改变。至今,左旋多巴仍然是治疗PD的主要手段,然而左旋多巴治疗PD的“蜜月期”是短暂的,
出处 《中华医学杂志》 CAS CSCD 北大核心 2009年第3期210-212,共3页 National Medical Journal of China
基金 教育部留学回国人员科研启动基金上海市教育委员会基金(06BZ048) 上海市浦江人才计划(PJ[2007]00346) 上海市科委上海一飞利浦研究与发展基金合作基金(07SP07005)
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参考文献23

  • 1Jankovic J. Motor fluctuations and dyskinesias in Parkinson's disease: clinical manifestations. Mov Disord, 2005, 20Suppl 11: S11-16.
  • 2Jankovic J. Parkinson's disease therapy: tailoring choices for early and late disease, young and old patients. Clin Neuropharmacol, 2000, 23:252-261.
  • 3Ahlskog JE, Muenter MD. Frequency of levodopa-related dyskinesias and motor fluctuations as estimated from the cumulative literature. Mov Disord, 2001, 16:448-458.
  • 4Pearce RK, Heikkila M, Linden IB, et al. L-dopa induces dyskinesia in normal monkeys: behavioural and pharmacokinetic observations. Psychopharmacology ( Berl), 2001, 156:402-409.
  • 5Fahn S. Parkinson's disease, the effect of levodopa, and the ELLDOPA trial. Arch Neurol, 1999, 56:529-535.
  • 6Fahn S. Results of the ELLDOPA ( earlier vs. later levodopa) study. Mov Disord, 2002, 17Suppl 5 :S13.
  • 7Vaamonde J, Ibanez R, Gudin M, et al. Fluctuations and dyskinesias as early L-dopa-induced motor complications in severe Parkinsonian's patients. Neurologia, 2003, 18 : 162-165.
  • 8Oliveri RL, Annesi G, Zappia M, et al. Dopamine D2 receptor gene polymorphism and the risk of levodopa-indueed dyskinesias in PD. Neurology, 1999,53 : 1425-1430.
  • 9Kaiser R, Hofer A, Grapengiesser A, et al. L -dopa-induced adverse effects in PD and dopamine transporter gene polymorphism. Neurology, 2003, 60 : 1750-1755.
  • 10Baas H. Dyskinesia in Parkinson's disease Pathophysiology and clinical risk factors. J Neurol, 2000,247 ( Suppl 4) : Ⅳ12-Ⅳ16.

二级参考文献11

  • 1Pearce RK, Heikkila M, Linden IB,et al.L-dopa induces dyskinesia in normal monkeys:behavioural and pharmacokinetic observations.Psychopharmacology (Berl), 2001,156:402-409.
  • 2Vaamonde J, Ibanez R, Gudin M,et al.Fluctuations and dyskinesias as early L-dopa-induced motor complications in severe Parkinsonian's patients.Neurologia, 2003, 18:162-165.
  • 3Chase TN, Oh JD.Striatal mechanisms and pathogenesis of parkinsonian signs and motor complications.Ann Neurol, 2000, 47(4 Suppl 1):S122-S129.
  • 4Nyholm D, Askmark H, Gomes-Trolin C, et al.Optimizing levodopa pharmacokinetics:intestinal infusion versus oral sustained-release tablets.Clin Neuropharmacol, 2003, 26:156-163.
  • 5Maratos EC, Jackson MJ, Pearce RK,et al.Both short- and long-acting D-1/D-2 dopamine agonists induce less dyskinesia than L-DOPA in the MPTP-lesioned common marmoset (Callithrix jacchus).Exp Neurol, 2003 ,179:90-102.
  • 6Zappia M, Annesi G, Quattrone A.Association study of dopamine D2, D3 receptor gene polymorphisms with motor fluctuations in PD.Neurology,2002,58:837.
  • 7Oh JD, Chase TN.Glutamate-mediated striatal dysregulation and the pathogenesis of motor response complications in Parkinson's disease.Amino Acids, 2002, 23:133-139.
  • 8Calabresi P, Giacomini P, Centonze D, et al.Levodopa-induced dyskinesia:a pathological form of striatal synaptic plasticity? Ann Neurol, 2000, 47(4 Suppl 1):S60-S68.
  • 9Blandini F.Adenosine receptors and L-DOPA-induced dyskinesia in Parkinson's disease:potential targets for a new therapeutic approach.Exp Neurol, 2003, 184:556-560.
  • 10Calon F, Grondin R, Morissette M, et al.Molecular basis of levodopa-induced dyskinesias.Ann Neurol, 2000,47(4 Suppl 1):S70-S78.

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