湖南省2003年8月至2007年7月加替沙星不良反应报表分析

Analysis of adverse drug reaction of gatifloxacin in Hunan province from Aug. 2003 to Jul. 2007

目的：通过总结加替沙星的不良反应（adverse drug reaction，ADR），为临床合理用药提供参考。方法：收集2003年8月至2007年7月湖南省ADR监测中心收到的1077例加替沙星ADR报表，并进行统计分析。结果：加替沙星所致ADR临床表现多样，能导致多系统一器官的ADR发生。1077例患者中，男性ADR发生率略低于女性；年龄为20—59岁人群发生ADR为821例（占76．23％）；静脉给药为905例（占84．03％）；消化系统损害最常见（682例次，33．07％），其次为皮肤及其附件损害（490例次，23．76％）和神经系统损害（298例次，14．45％）。结论：临床必须重视加替沙星ADR的监测和报道，以减少或避免ADR发生。

Objective To summarize the occurrences of adverse drug reactions （ADR） of gatifloxacin, and to guide the rational usage of antibacterial agents in clinical practice in the future. Methods A total of 1 077 ADR patient who received gatifloxacin were retrospectively studied in Hunan province from August 2003 to July 2007. Results Gatifloxacin could cause multi-system and multi-organ ADRs with wide variety of clinical manifestations. Of the 1 077 ADR patients, ADR incidence rate was slightly lower in males than that in females, the age of 821 （ 76.23 % ） ADR patients were 20 -59 years; 905 （84, 03% ） were administered intravenously; and 682 （33.07%） had severe lesions of the digestive system, followed by lesions of the skin and the appendants （490 cases, 23.76% ） and the nervous system （298 cases, 14.45% ）. Conclusion ADR caused by gatifloxacin should be monitored and reported so as to reduce or avoid ADR.