G蛋白激酶4基因多态性与高血压病相关性的Meta分析

Correlation between of G protein-coupled receptor kinases 4 polymorphism and essential hypertension:a Meta-analysis

目的综合评价G蛋白激酶4(G protein-coupled receptor kinases4,GRK4)基因多态性R65L、A486V、A142V与高血压病的相关性。方法检索Medline1997-2006年关于GRK4基因多态性(R65L、A486V、A142V)与高血压病相关性的文献,应用RevMan4.2软件对其进行Meta分析。结果共有4篇符合条件的文献纳入分析,累积病例857例,累积对照913例。GRK4变异体R65L、A142V、A486V3个基因型频率的合并OR值及95%CI值分别为0.97(0.75～1.25,P=0.81)、0.81(0.30～2.08,P=0.65)和1.48(1.16～1.89,P=0.001)。结论GRK4基因A486V多态性可能与原发性高血压相关,变异体A486V患者高血压病的危险性可能有增高趋势。

Objective To access the relationship between the polymorphism of G protein-coupled receptor kinases 4 （GRK4, including R65L, A486V and A142V） and essential hypertension. Methods All the literature on the subjects was searched by key words such as essential hypertension, hypertension, G protein-coupled receptor kinases 4 gene, and polymorphism in the electronic databases, Medline of Year 1997 to 2006. RevMan 4.2 software was used for Meta analysis. Results A total of 857 cases and 913 controls from 4 studies were included. The ORs of genotypes of R65L, A142V and A486V were 0.97 （0.75 to 1.25, P =0.81 ） , 0.81 （0.30 to 2.08, P = 0.65） and 1.48 （ 1.16 to 1.8, P = 0. 001 ） respectively. Conclusion GRK4 gene polymorphism A486V is significantly associated with susceptibility of essential hypertension. People who carries A486V have a higher risk to be subject to essential hypertension.