丹参注射液对大鼠骨骼肌急性钝挫伤后生物力学指标的影响

The effect of Salvia Miltiorrhiza injection on biomechanical index during repairing process after skeletal muscle contusion of rats

目的探讨丹参注射液在大鼠骨骼肌钝挫伤后修复过程中的作用。方法108只雄性SD大鼠,随机分为3组:丹参注射液组,自然愈合组,对照组。对丹参注射液组和自然愈合组大鼠采用打击装置造成其右侧腓肠肌钝挫伤,分别于伤后第14、21、28、35、42、56天取材,测试大鼠双侧腓肠肌的最大拉伸强度和最大拉伸率,并将每只大鼠的伤侧数值与健侧数值之比作为参数进行统计学分析,比较各组大鼠的统计结果。结果(1)最大拉伸强度方面:自然愈合组至第56天基本达到正常水平,丹参注射液组明显早于自然愈合组,于第42天即达到正常水平。(2)最大拉伸率方面:丹参注射液组和自然愈合组至第56天仍处于较低水平,自然愈合组明显低于丹参注射液组(P<0.05)。结论丹参注射液在促进骨骼肌钝挫伤愈合方面是有效的,不仅缩短了愈合时程,使骨骼肌在较短时间内达到一定的强度,而且能够有效地改善骨骼肌的愈合质量。

Objective To observe the effect of Salvia Miltiorrhiza injection during repairing process after skeletal muscle contusion of rats. Methods One hundred and eight male SD rats were randomly divided into three groups, including Salvia Miltiorrhiza injection group, natural healing group and control group. A standard contusion model was produced at the right gastrocnemius in 72 rats （Salvia Miltiorrhiza injection group, natural healing group）. At 14,21,28,35,42 and 56 days after injury, the biomechanical test was performed to measure the maximal tensile strength and maximal tensile rate between injured gastrocnemius and non-injured side as control. The results were compared and analyzed statistically. Results （1） Maximal tensile strength： In natural healing group, the maximal tensile strength of injured muscle was nearly approaching normal at 56 days after injury. The maximal tensile strength of injured muscle in Salvia Miltiorrhiza injection group achieved the normal level at 42 days, earlier than that in natural healing group. （2） Maximal tensile rate： In Salvia Miltiorrhiza injection group and natural healing group, the maximal tensile rate of injured muscle was obviously inferior to the normal even at 56 days after injury. In natural healing group, the maximal tensile rate of injured muscle was obviously inferior to that of the Salvia Miltiorrhiza injection group at 56 days after injury. Conclusions Salvia Miltiorrhiza injection is effective in skeletal muscle healing following trauma. Not only can it accelerate the process of skeletal muscle healing.