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组蛋白去乙酰化酶抑制剂的免疫抑制功能研究进展 被引量:3

Immunosuppressive function of histone deacetylases inhibitors:recent progress
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摘要 组蛋白去乙酰化酶抑制剂(histone deacetylases inhibitors,HDACIs)是一类在转录水平调控基因表达的化合物,通过诱导蛋白过乙酰化引起染色体重建、细胞周期停滞、诱导细胞分化和凋亡以及调节转录因子活化和抑制等一系列生物学效应。HDACIs在多种血液系统肿瘤和实体瘤中显示了明确而强大的抗肿瘤活性,目前已进入临床研究阶段。其在炎症免疫疾病动物模型及基础研究中显示出的免疫抑制活性,为探索从基因水平治疗炎症免疫性疾病及移植术后排斥反应带来了新思路。本文从炎症免疫性疾病、T淋巴细胞、促炎细胞因子及树突状细胞(dendritic cells,DCs)功能等几方面,对HDACIs参与的免疫调节功能研究进展作一综述。 Histone deacetylases inhibitors(HDACIs)are a group of compound regulating gene expression at transcriptional level.HDACIs can induce protein hyperacetylation and subsequently lead to chromatin remodeling,cell-cycle arrest,cell differentiation and apoptosis,and transcriptional activation and repression.HDACIs demonstrate promising antitumor activity and are presently tested in clinical studies for solid and hematologic malignancies.Cumulating evidence in animal models of immune disorders also suggests immunosuppressive properties of HDACIs,which provides us with new ideas for treating immune disorders and rejection after transplantation.This paper reviews the recent progress of immunosuppressive function induced by HDACIs from the following aspects:immune diseases,T lymphocytes,inflammatory cytokines and dendritic cells.
出处 《第二军医大学学报》 CAS CSCD 北大核心 2009年第1期80-83,共4页 Academic Journal of Second Military Medical University
基金 国家自然科学基金(30671973)~~
关键词 组蛋白脱乙酰基酶类 抑制剂 T淋巴细胞 免疫应答 移植排斥 histone deacetylases inhibitors T lymphocyte immunoresponse transplant rejection
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参考文献28

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同被引文献20

  • 1纪巧丽,林蓉,史晓莲,毛幼桦,翟小刚.双丙戊酸钠和丙戊酸钠对HepG2细胞的毒性作用及机制[J].中国药理学与毒理学杂志,2010,24(3):214-218. 被引量:9
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  • 3胡森,侯经元,李琳,等.丙戊酸钠对致死性休克犬脏器功能和病死率的影响[J].中国应用生理学杂志,2009,25(3):27.
  • 4张敏,李彪,张一帆.组蛋白去乙酰化酶抑制剂在抗肿瘤应用中的进展[J].国际放射医学核医学杂志,2007,31(5):270-273. 被引量:7
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