P53蛋白赖氨酸甲基化与去甲基化

Methylation and Demethylation on Lysine of P53 Protein

P53作为肿瘤抑制因子和转录调节因子在控制细胞周期、凋亡和DNA修复方面发挥重要作用。P53蛋白的稳定性和转录激活活性的调节主要依赖磷酸化、乙酰化、泛素化等多种翻译后修饰。最近研究发现一些组蛋白赖氨酸甲基转移酶和去甲基化酶可使P53蛋白C-端赖氨酸残基发生甲基化或去甲基化，调节P53蛋白的稳定性和转录激活活性。甲基化和去甲基化与其它翻译后修饰相互作用构成“P53密码”调节P53蛋白功能。

p53, the tumor suppressor and transcription factor, plays a pivotal role in controlling cell cycle, apoptosis and DNA repair. The stability and transcriptional activity of p53 are regulated mostly through multiple post-translational modifications, such as phosphorylation, acetylation, and ubiquitination. Recent studies have established that lysine methyhransferases and demethylase of histone specifically lead to methylation or demethylation of p53 protein at its C-terminal lysines, mediating stability and transcriptional activity of p53. The interplay between methylation, demethylation, and other post-translational modifications of p53 constitutes a ‘p53 code＇ regulating the function of p53.