基于Starling假设新发现的组织流场模拟

NUMERICAL SIMULATION OF INTERSTITIAL FLUID BASED ON A NEW VIEW OF STARLING'S HYPOTHESIS OF CAPILLARY WALL

根据微血管壁渗流的Starling假设新发现,对人体骨间膜的组织液流动进行数值模拟,讨论了组织间隙蛋白质非均匀分布对流动的影响.结果发现血管壁中对蛋白质有渗透屏障作用的纤维基质层,导致了组织空间蛋白质非均匀分布.靠近动脉端,高静水压引起毛细血管内液体的净流出,使组织蛋白无法扩散到血管壁附近;在静脉端,由于毛细血管内静水压较低,蛋白质可以扩散到血管壁附近.将组织空间蛋白质非均匀分布与传统的Starling模型假设的蛋白质浓度定常的数值模拟结果对比发现,两者组织液流动的速度有较大的差异,前者的最大速度是后者的一半,非均匀分布模型的模拟结果更符合实验观察的现象,说明组织间隙蛋白质的非均匀分布对组织液的流动很重要.

Interstitial fluid is the surroundings that cells live in. Spatial distribution of protein in interstitial space is not uniform. This article is to numerically investigate the interstitial fluid in interosseous membrane of lower limb based on a new view of Straling＇s hypothesis and to study the effect of unequal distribution of protein in the interstitial fluid. The results showed these parallel capillaries could lead to directional flow of interstitial fluid under the equal and unequal protein distribution conditions. The fiber matrix in the capillary wall opposed protein filtration induced the unequal distribution of protein. The high pressure in the capillary near the artery prevented protein from diffusing to the capillary wall to induce the lower protein concentration. Furthermore, the unequal spatial distribution of protein in interstitial space had a strong influence on the interstitial fluid flow. The numerical results in the present work were in good agreement with the experimental data from Weinbaum.