钴络合物催化双羰化氯苄合成苯丙酮酸

Cobalt complexes catalyzed double carbonylation of benzyl chloride for synthesis phenylpyruvic acid

α－酮酸是合成α－氨基酸和α－羟基酸的中间体．在Ｃｏ２（ＣＯ）８或Ｃｏ２（ＣＯ）８－Ｃｏ（ＰＰｈ３）ｍＸｎ催化下，苄基卤经双羰化合成苯丙酮酸，并初步研究了其反应机理．

Using Co2(CO)8 or Co2(CO)8Co(PPh3)mXn as catalyst,the double carbonylation of benzyl chloride with carbon monoxide in a Ca(OH)2/OOsystem gives the phenylpyruvic acid in good to excellent yields.The reaction mechanism is briefly discussed.