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雌激素通过SDF-1／CXCR4信号通路对乳腺癌的影响 被引量：3

Effect of estrogens on breast cancer through SDF-1/CXCR4 signaling pathways
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摘要 乳腺癌是一种激素依赖性肿瘤，雌激素水平升高与乳腺癌的发生密切相关。雌激素通过与其受体（ER）结合以及与雌激素本身代谢产物毒性2条途径参与乳腺癌的发生。近年研究发现基质细胞衍生因子-1（SDF-1）及其受体CXCR4与乳腺癌的关系十分密切，雌激素通过对SDF-1／CX—CR4信号通路的影响在乳腺癌的生长、增殖和转移中发挥作用。这些新的发现为乳腺癌的治疗提供了新的思路和靶点。 Breast cancer is a kind of hormone-dependent tumor, the high level of estrogens is an important risk factor of breast cancer. There is evidence that estrogens through estrogen receptor （ER） signaling pathways and estrogen metabolic products participate in the development and progression of breast cancer. Recentally, studies demonstrated that SDF-1 and its receptor CXCR4 are involved in breast cancer. Estrogens play an important role in the growth, proliferation and metastasis of breast cancers through SDF-1/CXCR4 signaling pathways. These findings may provide a novel therapeutic target for breast cancer.
作者 张锋良 康骅
机构地区 首都医科大学宣武医院普外科
出处 《国际外科学杂志》 2009年第1期51-54,共4页 International Journal of Surgery
关键词 雌激素 乳腺癌 基质细胞衍生因子-1 受体 estrogen breast cancer stromal cell-derived factor-1 CXCR4
分类号 R737 [医药卫生—肿瘤]
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参考文献17

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二级参考文献16

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共引文献6

同被引文献44

  • 1王婷玉,李俊.凋亡抑制蛋白的研究进展[J].安徽医药,2005,9(6):402-406. 被引量：8
  • 2孙蕾,谭文华,高展.凋亡抑制蛋白Livin、细胞凋亡与肿瘤治疗[J].中国优生与遗传杂志,2005,13(11):6-7. 被引量：6
  • 3孙建国,廖荣霞,陈正堂,王志新,张青,胡义德,王东林.Livin异构体基因转染对肺腺癌A549细胞生长及放化疗敏感性的影响[J].中华结核和呼吸杂志,2005,28(12):836-840. 被引量：20
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国际外科学杂志
2009年 第1期

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