氧化LDL抗体对颈动脉粥样硬化斑块发生影响

Relationship between antibodies against oxLDL and occurrence of carotid atherosclerosis plaques

目的探讨氧化低密度脂蛋白抗体(oxLDL-Ab)在颈动脉粥样硬化斑块发生中的作用。方法通过颈动脉超声检查确诊存在颈动脉粥样硬化斑块的患者60例,对照143例。采用酶联免疫吸附实验(ELISA法)测定ox-LDL-Ab水平,同时测定血压、血脂、体质指数(BMI)等可能的影响因素。结果病例组oxLDL-Ab含量为(15.4±8.8)U/ml,低于对照组的(32.3±20.4)U/ml。控制各种可能的混杂因素后,oxLDL-Ab仍然与颈动脉粥样硬化斑块的发生有关(P=0.001,OR=0.919,95%CI=0.876～0.965)。结论oxLDL-Ab在颈动脉粥样硬化斑块的发生中可能具有保护作用。

Objective To investigate the role of antibodies against oxidized low-density lipoprotein （oxLDL-Ab） in the occurrence of atherosclerosis plaques. Methods A case-control study was conducted. Sixty cases with atherosclerosis plaques were diagnosed through carotid ultrasonography examination. One hundred and forty three normal subjects were chosen as the control group. The levels of oxLDL-Ab were determined by enzyme linked immunosorbent assay（ELISA）. Blood lipids and BMI were also measured for multivariate analysis. Results The concentration of oxLDL-Ab was 15.4 ± 8. 8 U/ml in the patients, while it was 32. 3 ±20.4 U/ml in the control group. The level of oxLDL-Ab in the patients was significantly lower than that of in the control group. The level of oxLDL-Ab was negatively correlated with atherosclerosis plaques after controlling confounding factors （ P = 0. 001, OR = 0. 919,95 % CI： 0. 876 - 0. 965 ）. Conclusion The antibodies against oxLDL may play a protective role in the occurrence of atherosclerosis plaques.