尿mAlb/Cr、NAG、LAP检测对早期糖尿病肾病的诊断价值

Value of urine mAlb,NAG and LAP for diagnosing early diabetic nephropathy

目的研究糖尿病患者的尿液微量白蛋白/肌酐(mAlb/Cr)、N-乙酰-β-D氨基葡萄糖苷酶(NAG)、亮氨酸氨基肽酶(LAP)与早期糖尿病肾病(DN)的诊断价值关系。方法将216例糖尿病患者分为两组:糖尿病无肾病组与早期糖尿病肾病组,采用免疫比浊法测定尿微量白蛋白/肌酐,采用速率法检测尿NAG及LAP值,并与49例健康对照组比较。结果糖尿病肾病患者尿mAlb/Cr、NAG、LAP明显高于对照组(P<0.01),且尿微量白蛋白/肌酐与NAG,LAP成正相关(r=0.909,r=0.410,P<0.01)。结论检测尿mAlb/Cr、NAG、LAP有助于尿蛋白阴性的糖尿病肾病的早期诊断。

[Objective] To investigate the value relationship of urine mAlb/Cr, N-acety-β-D-glucosaminidase （NAG） and Leucine Aminopeptidase （LAP） for early diagnose of early diabetic nephropathy （DN）. [Methods] Urine albumin was detected by immunity turhiktimctric method. NAG and LAP were detected by rate assay .They were detected in 216 cases of diabetics who were DN or non-DN and 49 normal persons. [Results] The levels of Urine mAlb/Cr, urine NAG and LAP were obviously higher than those in controls （P 〈0.01）. The urine mAlb/Cr and NAG and LAP showed positive correlation （r =0.909, r =0.410, P 〈0.01）. [Conclusions] The detection of urine mAlb/Cr and NAG and LAP with urinary albumen negative is conducive to the early diagnosis of DN.