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促进移植干细胞存活、分化和修复坏死心肌的策略 被引量：6

Strategies for promoting survival,differentiation of stem cells after transplantation and repairing ischemic myocardium
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摘要 移植干细胞在缺血心肌微环境中的低存活率是影响干细胞移植治疗效果的关键。通过采取干预措施即利用细胞因子、药物、化合物等对移植干细胞进行体外预处理,或采用有利于干细胞存活、黏附或促进血管形成的基因对干细胞进行修饰,可直接和间接地提高干细胞在缺血心肌微环境中的存活和分化能力,从而有助于促进移植干细胞修复坏死心肌和改善心功能。 The low survival rate of stem cells in the ischemic myocardium microenvironment is the bottle neck in treating ischemie diseases with stem cell transplantation. It is able to increase anti-apoptotic ability of the stem cells and promote their effective differentiation towards myocardial cells directly and indirectly by pretreating the stem cells with cytokines, drugs or chemical compounds, or modifying gene expression to promote cell adhesion, survival or angiogenesis for repairing ischemic myocardium and improving heart function after transplantation of the stem cells.
作者 崔晓军 谭玉珍 王海杰
机构地区 复旦大学上海医学院人体解剖学与组织胚胎学系
出处 《基础医学与临床》 CSCD 北大核心 2009年第1期97-101,共5页 Basic and Clinical Medicine
基金 国家自然科学基金(30470883)
关键词 干细胞 存活 分化 细胞移植 心肌修复 stem cell survival differentiation cell transplantation cardiac repair
分类号 R54 [医药卫生—心血管疾病]
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参考文献22

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二级参考文献42

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共引文献17

同被引文献63

  • 1孟洁,孔桦,朱广瑾,许海燕.纳米纤维结构支架的构建及其对再生医学的意义[J].基础医学与临床,2006,26(7):689-693. 被引量：10
  • 2唐毅,魏英杰,胡盛寿,张浩.SDF-1-CXCR4轴与缺血性心脏病的干细胞治疗[J].基础医学与临床,2006,26(8):915-921. 被引量：3
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引证文献6

二级引证文献4

基础医学与临床
2009年 第1期

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