癌基因诱导的细胞衰老

Oncogene-induced cellular senenscence

癌基因诱导的衰老(OIS)是指癌基因突变所产生的异常增殖信号,通过MAPK和PI3K信号通路,使细胞处于生长停滞的状态,抑制细胞增殖。它的发生机制与异染色质的形成以及DNA损伤检测点反应的作用相关。衰老相关的β-半乳糖苷酶和异染色质灶是OIS的标记。随着人们对OIS的认识,新的肿瘤发生模式不断提出。对OIS机制的了解,有利于我们重新认识肿瘤的发生机制,为肿瘤治疗提供新的思路和方法。

Oncogene-induced senenscence （OIS） is defined as a stable proliferative arrest of normal cells upon overexpression of aberrant proliferative signals of oncogenes through MAPK and PI3K pathway. The molecular mechanism of OIS is related to the formation of heterochromatin and DNA-damage check-point response. The markers of OIS includ senescence-associated β-galactosidase and senescence-associated heterochromatin foci. With the growing recognization of OIS, the new models of tumor progression are emerging. The further investigation on the mechanism of OIS is of great significance to understanding of the tumorigenesis and provide new ideas and methods of cancer treatment.