黏着斑激酶与纤维化

Focal adhesion kinase and fibrosis

黏着斑激酶(FAK)是一种非受体胞质酪氨酸蛋白激酶,处于细胞内多条信号传导通路的交汇点,活化后可调节多种细胞生物学行为。研究发现,FAK在多种纤维化疾病的发生发展中发挥重要作用,有可能成为纤维化疾病治疗的新途径。

Focal adhesion kinase （FAK）, a non-receptor protein tyrosine kinase, is siting at the cross road of numerous intra-cellular signal transduction. The activated FAK has been implicated in a diverse array of cellular behavious. Recent research on FAK and fibrosis show that FAK plays an important role in fibrosis disease, so the targeting of FAK may be a novel therapeutic strategy.