DNA甲基化的生物信息学研究进展

Progress of Bioinformatics Study in DNA Methylation

作为重要的表观遗传学现象之一,DNA甲基化对基因的表达发挥重要的调控功能.随着高通量检测技术的不断发展,对DNA甲基化的生物信息学研究也成为DNA甲基化研究中的一个非常活跃的热点.对生物信息学在DNA甲基化状态的预测、CpG岛不易被甲基化的机制研究、探索DNA甲基化同其他表观遗传学现象之间的关系以及DNA异常甲基化同癌症的发生和发展之间的关系等方面的研究进展进行综述.

DNA methylation is an important epigenetic system. It plays many crucial roles in the gene regulation. With the development of the high-throughput detection techniques, the bioinformatics study has been an active hot topic in the research of DNA methylation. The major achievements and progress on the prediction of DNA methylation status, the mechanism that the majority of CpG islands are resistant to DNA methylation, the relationship between DNA methylation and other epigenetics, as well as the association between aberrant DNA methylation and the tumorigenesis were reviewed in this article.