芬太尼复合氟比洛芬酯用于食管癌术后静脉自控镇痛的可行性

Feasibility study of fentanyl with flurbiprofen axetil for postoperative patient controlled intravenous analgesia in patients underwent resection of esophageal carcinoma

目的：评价芬太尼复合氟比洛芬酯用于食管癌术后静脉自控镇痛（PCIA）的可行性。方法：ASAⅠ～Ⅱ级食管癌根治术患者40例，随机均分为两组，A组，术后PCIA芬太尼1．0mg、氟哌利多2．5mg；B组，麻醉前静注氟比洛芬酯50mg，术后PCIA芬太尼0．5mg、氟比洛芬酯50mg、氟哌利多2．5mg，均用生理盐水稀释为100ml。记录术后1、2、4、8、12、24、36、48h的镇痛评分（VAS）、Ramesay镇静评分、PCIA按压次数及不良反应。结果：术后PCIA按压次数与各时点的VAS两组间差异无统计学意义。B组Ramesay评分及恶心呕吐发生率低于A组。结论：芬太尼复合氟比洛芬酯用于食管癌根治术术后静脉自控镇痛的效果良好，且能减少芬太尼用量，同时降低不良反应的发生。

Objective ： To evaluate the efficacy and safety of flurbiprofen axetil combining with fent- anyl for postoperative patient controlled intravenous analgesia （PCIA）in patients underwent resection of esophageal carcinoma. Methods ：Forty ASA class Ⅰ～Ⅱ patients were equally randomly di- vided into two groups ： group A （fentanyl 1.0 mg＋ droperidol 2.5 mg）, group B （fentanyl 0.5 mg ＋ flurbiprofenaxetil 50 mg ＋ droperidol 2.5 rag） , and group B was additionally intravenous injection of flurbiprofen axtil 50 mg prior to the surgery. The VAS score, Ramsay sedation scale, PCIA pressing times and the adverse effects were recorded at 1,2, 4, 8, 12, 24, 36,48 hours after surgery. Results：Patients in the two analgesic groups did not show any significant difference in the VAS scores and PCIA pressing times （P 〉 0.05）. Ramsay sedation scale, the incidence rate of adverse events such as nausea and vomiting in group A were significantly higher than those in group B. Conclusion ： Co-administration of fentanyl with flurbiprofen axetil by PCIA offers overall favorable analgesic responses as well as the reduction of fentanyl consumption during PCIA in the patients following esophageal carcinoma surgery.