摘要
SLC2A2基因是溶质转运家族2的成员之一,其编码蛋白分布于肝脏、胰腺、肾脏、下丘脑等组织,调节细胞对葡萄糖的摄取,具有重要的生理功能。研究表明SLC2A2基因的变异与糖尿病、Fanconi-Bickel综合征等糖代谢异常的疾病的发生息息相关。
出处
《中国优生与遗传杂志》
2009年第2期1-2,共2页
Chinese Journal of Birth Health & Heredity
参考文献22
-
1Fukumoto H, S Seino, H Imura-, et al. Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein[J]. Proc Natl Acad Sci U S A, 1988,85 ( 15 ) : 5434 - 5438.
-
2Matsutani A, L Koranyi, N Cox, et al. Polymorphisms of GLUT2 and GLUT4 genes. Use in evaluation of genetic susceptibility to NIDDM in blacks[J]. Diabetes, 1990,39 ( 12 ) : 1534 - 1542.
-
3Li S R, J C Alcolado, J Stocks, et al. Genetic polymorphisms at the human liver/islet glucose transporter (GLUT2) gene locus in Caucasian and West Indian subjects with type 2 ( non - insulin - dependent) diabetes mellitus [ J]. Biochim Biophys Acta, 1991,1097 (4) : 293 - 298.
-
4Shimada F, H Makino, H Iwaoka, et al. Identification of two novel amino acid polymorphisms in beta - cell/liver ( GLUT2 ) glucose transporter in Japanese subjects [ J ]. Diabetologia, 1995,38 (2) :211 - 215.
-
5Tanizawa Y, A C Riggs, K C Chiu, et al. Variability of the pancreatic islet beta cell/liver ( GLUT 2 ) glucose transporter gene in NIDDM patients [J]. Diabetologia, 1994,37 (4) : 420 - 427.
-
6Mueckler M, M Kruse, M Strube, et al. A mutation in the Glut? glucose transporter gene of a diabetic patient abolishes transport activity [ J ]. J Biol Chem, 1994,269 ( 27 ) : 17765 - 17767.
-
7Barroso I, et al. Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta - cell function as well as insulin action [J]. PLoS Biol,2003,1 ( 1 ) : E20
-
8Cha J Y, et al. Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity[J]. Ann Clin Lab Sci,2002,32(2) : 114 - 122.
-
9Laukkanen O, J Lindstrom, J Eriksson, et al. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes : the Finnish Diabetes Prevention Study[ J ]. Diabetes,2005,54 (7) :2256 - 2260.
-
10Kilpelainen T O, T A Lakka, D E Laaksonen, et al. Physical activity modifies the effect of SNPs in the SLC2A2 ( GLUT2 ) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes [J]. Physiol Genomics,2007,31 (2) :264 - 272.
同被引文献4
-
1Kilpelainen TO, Lakka TA, Laaksonen DE, et al. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. Physiol Genomics, 2007, 31:264-272.
-
2Cha JY, Kim HS, Kim HI, et al. Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity. Ann Clin Lab Sci, 2002, 32:114-122.
-
3Wangler MF, Chang AS, Moley KH, et al. Factors associated with preterm delivery in mothers of children with Beckwith Wiedemann syndrome: a ease cohort study from the BWS registry. AmJ Med Genet A, 2005, 134A:187-191.
-
4Takimoto E, Ishida J, Sugiyama F, et al. Hypertension induced in pregnant mice by placental renin and maternal angiotensinogen. Science, 1996, 274:995-998.
-
1占志云,徐国兴.水通道蛋白与年龄相关性白内障关系的研究进展[J].国际眼科杂志,2011,11(12):2122-2124. 被引量:1
-
2余燕婷,俞雨生.Claudin介导溶质转运与腹膜转运功能[J].肾脏病与透析肾移植杂志,2009,18(2):177-180. 被引量:1
-
3许国章,张普生,唐晓红.CAPD液体和溶质传递的生物物理学和临床应用(续)[J].生物医学工程学杂志,1992,9(1):91-96. 被引量:1
-
4刘映红,成梅初,朱笑萍,刘伏友,袁芳.腹膜透析相关性腹膜炎兔模型的建立[J].湖南医科大学学报,2001,26(6):573-576. 被引量:2
-
5刘思明,叶任高,彭文兴,李鵔,王莹,汪涛.振摇对腹膜表面层和腹膜功能的影响[J].中国病理生理杂志,2005,21(6):1163-1166. 被引量:1
-
6石磊.高通量透析膜在血液透析中的应用[J].中国组织工程研究与临床康复,2011,15(25):4703-4706. 被引量:24
-
7严豪,方炜,李振元,林爱武,曹励欧,袁江姿,倪兆慧,钱家麒.可溶性酪氨酸激酶2融合蛋白对尿毒症腹膜透析大鼠腹膜形态和功能的影响[J].中华肾脏病杂志,2010,26(7):525-529. 被引量:6