核黄素在烧伤创面上的应用

Use of riboflavin lactochrome on burn wounds

目的:观察核黄素对中、小面积烧伤浅Ⅱ°、深Ⅱ°创面的治疗效果,并评价其药物不良反应。方法:选择160例浅Ⅱ°和80例深Ⅱ°中、小面积烧伤患者,将患者创面治疗分为核黄素组和磺胺嘧啶银(SD-Ag)组,观察各组创面完全愈合时间;指定时间创面愈合率;创面细菌培养情况;核黄素用于创面的疗效和安全性及对创面的刺激性等。结果:浅Ⅱ°创面:核黄素组完全愈合时间为(9.3±2.8)d,(SD-Ag)组为(11.0±3.5)d,P<0.01;用药后7d创面愈合率分别为(78.3±21.5)%及(64.8±23.0)%,P<0.01;深Ⅱ°创面:核黄素组完全愈合时间为(20.9±4.7)d,SD-Ag组为(23.8±6.5)d,P<0.01;用药后20d创面愈合率分别为(87.8±16.4)%及(77.6±18.5)%,P<0.01。上述数据差异均有统计学意义。同等深度烧伤创面核黄素组与SD-Ag组比较,创面均未发生感染情况,细菌学调查差异均无统计学意义(P>0.05),核黄素比SD-Ag刺激性更小。结论:核黄素是一种可用于浅Ⅱ°、深Ⅱ°中、小面积烧伤创面的有效,安全的外用药,在国内首创中、小面积烧伤创面不使用抗生素。

OBJECTIVE To evaluate the therapeutic effect of riboflavin on middle and small area partial-thickness burn wounds, and observe its side-effects. METHODS One hundred and sixty patients with superficial partial-thickness burns, and 80 with deep partial-thickness burns were randomized into riboflavin group and SD-Ag group. The wound healing time, wound healing rate and bacterial culture of the wound, the effect and safety of riboflavin, as well as irritation to the wounds were studied in these two groups. RESULTS For the patients with superficial partial-thickness burn wounds , the wound healing time in riboflavin group was （9. 3 ± 2. 8）days, which was evidently shorter than that in SD-Ag group （11.0± 3.5）days, P〈0. 01. The wound healing rate in riboflavin group was （78. 3 ± 21.5）%, which was evidently higher than that in SD-Ag group （64. 8 ± 23. 0）%, P〈0. 01. For those with deep partial thickness burn wounds, the wound healing time in lactochrome group was （20. 9 ± 4. 7）days, which was obviously shorter than that in SD-Ag group （23. 8 ± 6. 5）days, P〈0. 01. The wound healing rate in riboflavin group was （87. 8 ± 16. 4）%, which was obviously higher than that in SD-Ag group （77. 6 ± 18. 5）%, P〈0. 01. All the data differences above had statistical significance （P〈0. 01 ）. None of the burn wounds had infection in these two groups, but riboflavin was less irritating than SD-Ag cream. CONCLUSION Riboflavin is an effective and safe medicament for the clinical management of middle and small area partial-thickness burn wounds. And we healed partial-thickness burn wounds without antibiotic for the first time in our country.