人正常离体子宫动脉血管网三维模型的构建及意义

The construction of human normal uterine arterial vascular network model in vitro and its significance

目的研究人子宫动脉血管网表达的特点及意义。方法2008年9月南方医科大学南方医院妇产科获取正常成年新鲜离体子宫、双附件及阴道一套,应用血管铸型技术构建人正常离体子宫动脉血管网模型,观察子宫动脉血管网的形态及血供分布情况。结果(1)构建的人子宫动脉血管网模型可清楚显示子宫动脉及其各级分支的走行,表现在:①子宫动脉自主干依次分出膀胱支、输尿管支、上行支和下行支等分支动脉。②子宫动脉上行支沿途向宫体分出数条弓状动脉,在宫底部分出卵巢支、输卵管支和宫底支,弓状动脉再发出若干螺旋动脉。(2)观察子宫动脉血管网模型发现:①子宫动脉存在明显的同侧供血倾向,双侧子宫动脉在子宫的中轴线处存在交通支,但较为细小。②子宫动脉上行支主要向宫体及双附件供血,而下行支主要向宫颈供血,较少向阴道供血。结论采用血管铸型技术可构建理想的离体人子宫动脉血管网模型,为系统研究人子宫动脉血管网的解剖形态及血供分布提供了血管解剖学基础。

Objective To construct the three-dimensional（3D） model of uterine arterial vascular network in vitro through vascular casting for studying its characteristics and significance. Methods We collected a set of specimen with uterus, vagina and annex from healthy women from the department of obstetrics and gynecology in Nanfang Hospital of Southern Medical University in Sep. 2008,infused with 20% chlorinated poly vinyl chloride through the uterine artery and the ovarian artery,and then corroded, to reconstruct the uterine arterial vascular network model and observe its appearance and blood supply. Results （ 1 ）The model of uterine artery vascular network showed the course of the uterine artery as follows： （1）The uterine artery divided into several branches to the bladder, the ureter, the ascending branch and the ramus descendens. （2）The ascending branch divided into several arcuate arteries ,some of which then divided into the latter branches to the ovary, the fallopian tube and the fundus of uterus,and then divided into several helicine arteries. （2） It was found that from the model： （1）The unilateral uterine artery supplied blood with the homonymy of uterus. It showed the communicating branches of the bilateral uterine artery in the border, but the vascular network showed poorly. （2）The ascending branch supplied blood with the fundus of uterus and the adnexas. The ramus descendens from the uterine artery was the main artery for suppling blood with the cervix, and supplied little blood with the vagina. Conclusion It is a effec- tive way for constructing the normal uterine arterial vascular network model,which is beneficial for studying the anatomy and blood supply of the uterine artery.