c—myb和PARP基因蛋白在食管癌、胃癌中的表达

c-myb and PARP Gene Protein in Esophagus Cancer and Stomach Cancer Expression

目的揭示c—myb，PARP基因蛋白在食管癌、胃癌中的表达及意义，探讨其在人食管癌、胃癌发生、发展及预后中的作用。方法免疫组化染色采用SP法，观察c—myb，PARP基因蛋白在胃癌（41例）、食道癌（45例）组织中的表达，用t检验进行统计学处理。结果c—myb，PARP基因蛋白在食管癌、胃癌组织中有高表达，与癌旁组织的阳性表达率有显著性差异（P〈0．01）。正常组织中c—myb为阴性，PARP基因蛋白在食管组织中为2．1％、胃组织中为1．7％。结论c—myb，PARP基因蛋白在食管癌、胃癌中的表达，对这两种疾病的早期诊断、早期治疗及预后都具有现实意义，对开展新型治疗方法有着长远意义。

Objective To show the expression and significance of c-myb and PARP genoprotein in esophageal cancer and gastric carcinoma, and evaluate the importance of them in the development,progression and prognosis. Methods C-myb and PARP were statistically analyzed with the aid of t-tests on sections stained immunohistochemically for the expression in esophageal and gastric carcinomal tissues （n= 45,n= 41）. Results C-myb and PARP were highly expressed in both tissues, significantly different with paracarcinomal tissue having positive incidence （P〈0. 01）. In normal tissue,c-myb was negative; PARP 2.1% in esophageal tissue, 1.7% in gastric tissue. Conclusion The expression of c-myb and PARP in both tissues suggest that they are now-being to early diagnosis ,early treatment and prognosis ,and long-lasting to develop new treatment methods.