亚胺培南治疗中老年呼吸道感染的微生态研究

Study on the Microeclogy of Respiratory Tract Infection in the Old People by Treating with Imipenem

目的以亚胺培南作为监测药物，观察中老年患者治疗过程中呼吸道局部微生态菌群变化规律，以期指导临床合理用药。方法采集108例呼吸道感染用亚胺培南治疗的中老年患者治疗前后痰标本以及54例健康中老年对照组晨痰进行培养、定量计数及鉴定。分析亚胺培南治疗过程中，中老年患者呼吸道局部微生态变化情况。结果感染患者与健康对照组呼吸道菌群数量及分布有明显差异（P〈0．05）；亚胺培南治疗前后各菌群分布有明显差异（P〈0．05）；亚胺培南治疗前后呼吸道主要致病菌发生明显变化。结论呼吸道菌群失调可导致呼吸道感染，经亚胺培南治疗后呼吸道各菌群和主要致病菌均发生改变，亚胺培南对多数呼吸道致病菌治疗有效，但应注意筛选出耐亚胺培南菌株，合理应用抗生素。

Objective To study on the changes and tendency of the microeclogy of respiratory tract infection in the old people by imipenem（IPM） treating,in order to help the clinical training. Methods 108 old patients with respiratory tract infection by IPM treating and 54 healthy old patients were examined septums by qualitative,quantitative indentation. Analysis the changes of microeclogy of respiratory tract in the old people by IPM treating. Results The quantity and distribution in the infection group have the different with the health group （P〈0. 05）. The distribution of the flora and main pathogen bacteria were changed significantly after IPM treating. Conclusion The respiration tract bacteria groups imbalance result in the respiratory infection. After treating by IPM ,the flora and main pathogen bacteria were changed ,and IPM was useful of the main pathogen bacteria ,but must pay attention to the resistant bacteria.