低剂量γ射线辐照对红细胞抗氧化能力的影响

Effect of Low Dose γ-ray Radiation on the Antioxidation Capacity of Blood

目的探讨低剂量γ射线辐照全血对红细胞抗氧化能力的影响。方法20份人全血，以剂量为1Gy的γ射线进行辐照，吸收剂量率为17Gy／min，分别于照射前及照射后1h，2h取样检测红细胞超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH—Px）活力及血浆中丙二醛（MDA）含量。结果低剂量γ射线辐照1h，2h红细胞中SOD及GSH—PX活力明显高于照射前（P〈0．01），血浆中MDA含量明显低于照射前（P〈0．01）。结论全血经1Gy的7射线辐照后，增强红细胞抗氧化能力，阻止自由基对免疫细胞膜的损伤。

Objective To study the effect of low dose γ-ray radiation on the antioxidation capacity of red blood cells. Meth- ods Blood were radiated with γ-ray at the dose of 1Gy,after radiated at different time, they were taken as samples to measure the activity of SOD and GSH-Px as well as the MDA contents. Results Compared with the before radiated,the SOD activity and GSH-Px activity of RBC were increased on 1h,2 h respectively（P〈0. 01）. The MDA contents in blood plasma significantly were decreased on before radiated（P〈0. 01）. Conclusion Blood were after radiated with γ-ray at the dose of 1Gy,the antioxidation capacity of red blood cell increased and the imparement of cell embrane was decreased.