期刊文献+

白细胞介素-21及其受体与相关疾病的研究进展

下载PDF
导出
摘要 白细胞介素-21(IL-21)具有广泛的免疫调节生物学功能,而这些功能的发挥又必须依赖其受体(IL-21R)的存在和协同作用。IL-21与IL-21R结合后,通过细胞内JAK/STAT信号传导通路,并将信号传导给下游效应分子,促进B细胞的增殖分化,免疫球蛋白的生成;
出处 《现代检验医学杂志》 CAS 2009年第1期140-142,共3页 Journal of Modern Laboratory Medicine
  • 相关文献

参考文献25

  • 1Parrish-Novak J,Dillon SR, Nelson A,et al. Interleukin21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function[J]. Nature,2000,408(6808):57-63.
  • 2Davis ID, Skak K, Smyth MJ, et al. Interleukin-21 signaling: functions in cancer and autoimmunity[J]. Clin Cancer Res , 2007,13 (23) : 6926-6932.
  • 3Ozaki K,Spolski R,Feng CG,et al. A critical role for IL-21 in regulating immuno-globulin Production[J]. Science, 2002,298 (5598) : 1630-1634.
  • 4Kuchen S,Robbins R, Sims GP,et al. Essential role of IL-21 in B cell activation,expansion, and plasma cell generation during CD4^+ T cell-B cell collaboration[J]. J Immunol, 2007,179 (9) : 5886-5896.
  • 5Laurence G, Nathalie H, Maximilian W, et al. IFN- (gamma)-Mediated Inhibition of Human IgE Synthesis by IL-21 Is Associated with a Polymorphism in the IL-21R Gene [J]. The Journal of Immunology, 2006,177 : 5006-5013.
  • 6Strengell M,Sareneva T,Foster D,et al. IL-21 upregulates the expression of genes associated with in- nate immunity and Th1 response [J]. d Immunol, 2002,169 : 3600-3605.
  • 7Caprioli F,Sarra M ,Caruso R ,et al. Automatic regulation of IL-21 production in human T lymphocytes[J]. J Immunol , 2008,180(3) : 1800-1807.
  • 8Zeng R ,Spolski R,Casas E,et al. The molecular basis of IL-21-mediated proliferation[J]. Blood, 2007, 109(10) :4135-4142.
  • 9Deborah H,Thomas PB,Spencer L,et al. IL-21 Has a Pathogenic Role in a Lupus-Prone Mouse Model and Its Blockade with IL-21R. Fc Reduces Disease Progression[J]. The Journal of Immunology, 2007,178 : 3822-3830.
  • 10Bubier JA,Bennett SM,Sproule TJ,et al. Treatment of BXSB-Yaa mice with IL-21R-Fe fusion protein minimally attenuates systemic lupus erythematosus[J]. Ann N Y Acad Sci ,2007,1110:590-601.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部