动脉粥样硬化危险因子与脑动脉狭窄分布的相关分析

Study on Association between Atherosclerotic Risk Factors and Distribution of Cerebral Artery Stenosis

目的探讨动脉粥样硬化危险因子与脑动脉狭窄分布的关系。方法选择连续行主动脉弓＋全脑血管造影检查的成年缺血性脑血管病患者438例，根据脑动脉狭窄部位分为单独颅内狭窄（150人）、单独颅外狭窄（126人）、颅内外并发狭窄（162人）三组，比较三组间动脉粥样硬化危险因子的差异。结果颅外狭窄组、颅内外并发狭窄组凝血因子I（纤维蛋白原）水平均显著高于颅内狭窄组（P均〈0．05），而这两组间差异无统计学意义（P〉0．05）。三组间CRP水平比较，只有颅内外并发狭窄组水平显著高于颅内狭窄组（P〈0．05）。三酰甘油等其它因子各组闻比较差异均无统计学意义（P均〉0．05）。结论炎症标志物，而非传统危险因子，与脑动脉狭窄分布有关。

Objective To investigate the association between atherosclerotic risk factors and distribution of cerebral artery stenosis. Methods 438 adult patients with cerebral large-artery stenosis confirmed by angiography were divided into the alone intracranial stenosis,only extracranial stenosis and combined stenosis group. The difference of atherosclerotic risk factors among the three groups was analyzed. Results The fibrinogen levels of the only extracranial stenosis and combined stenosis group were significantly higher than that of the alone intracranial stenosis group （all P〈0. 05）, but no significant difference was found between the only extracranial stenosis and combined stenosis group. The significant difference in the CRP levels was found only between the alone intracranial stenosis and combined stenosis group （P〈0. 05）. The other atherosclerotic risk factors were not association with the distribution of cerebral artery stenosis. Conclusion Inflammatory markers,rather than conventional risk factors,are associated with the distribution of cerebral artery stenosis.