胃癌组织中P16蛋白的异常表达与临床病理学意义

Abnormal Expression of P16 Protein in Gastric Carcinoma Tissues and Clinicopathological Significance

目的:通过研究P16蛋白表达与胃癌发生及胃癌临床病理因素的关系,以探讨检测P16蛋白在胃癌诊断及判断胃癌恶性程度、估计预后和指导临床治疗的临床病理学意义。方法:采用免疫组化S-P法,检测100例胃癌与20例正常胃黏膜组织中P16蛋白表达情况。结果:P16蛋白在胃癌中表达率(36.0%)明显低于正常胃黏膜组织(85.0%)(P<0.01);P16蛋白表达与肉眼类型、分化程度、浸润深度、淋巴结转移,TNM分期有关(P<0.05);P16蛋白表达与患者性别、年龄、原发灶部位无关(P>0.05)。结论:检测P16蛋白的表达对辅助胃癌的诊断有很高的价值,并可作为判断胃癌恶性程度、估计预后和指导临床治疗的临床病理参考指标。

Objective： To study the relations between the expression of P16 and the genesis of gastric carcinoma and the clinico-pathological characteristics of gastric carcinoma, and to investigate the clinicopathological significance of detection P16 on diagnosis of gastric carcinoma, degree of malignant, prognostic appreciation and clinical treatment. Methods： Expressions of P16 were examined by S-P immunohistochemical staining in 20 cases of normal gastric mucosas and 100 cases of gastric carcinoma. Results： The positive rate of P16 expression in gastric carcinoma was 36.0%, lower than that in nomal gastric mucosas （85.0%）（ P 〈0.01）; it is related to the differ- entiation, invasion, metastasis by lymphatics, and staging of TNM （P 〈0.05）, but has nothing to do with sex, age, and situs of affection （P〉0.05）. Conclusions： The detection of P16 is highly valued to diagnose gastric carcinoma and to evaluate the degree of malignant, prognostic appreciation and clinical treatment on gastric carcinoma.