胃癌相关MicroRNA的研究

The Research of Gastric Cancer-related MicroRNA

microRNA是一种内源性的大小在20nt左右的一类非编码RNAs,其通过下调靶基因的表达或翻译而参与调节细胞的发育、增殖、分化、凋亡。近期研究发现microRNA具有癌基因和抑癌基因的作用,已发现miR-21,miR-191,miR-223,let-7ami-croRNA,miR-106b-25亚群等与胃癌的发生,let-7microRNA,miR-155与胃癌的侵袭与转移相关,miR-15,miR-16则参与胃癌的耐药机制。对其相应的调控机制和靶基因E2F1,PRL-3,HMGA2,BCL-2等的研究也已有了一些进展,为胃癌的研究开辟了一条新途径。本文就胃癌相关MicrRNA的研究进展予以综述。

microRNA are endogenous non-coding RNAs about 20nt that can play important regulatory roles in development, proliferation, differentiation and apoptosis with respect to cells by negatively controlling expression or translation on target mRNA. Recent studies indicate that microRNA can function as both oncogene and anti-oncogene, miR-21, miR-191, miR-223, let-7a microRNA, miR-106-25 cluster etc. have been demonstrated to be related with tumorigenesis, and let-7 microRNA and miR-155 are reported to be involved in invasiveness and metastasis, while miR-15 and miR-16 are regarded to be correlated with multidrug resistance in gastric cancer. There are already much advancement in research of the regulatory mechanism and target genes, as E2F1, PRL-3, HMGA2, BCL-2 and so forth, which might provide a new way in studying gastric cancer. This article reviewed the research advancement about microR- NA in gastfic cancer.