准献血人群人类巨细胞病毒检测的临床价值

Role of human cytomegalovirus detection in clinical blood transfusion safety assessment of prospective blood donors

目的:检测和分析准献血人群人类巨细胞病毒(HCMV)的感染现状,为临床安全输血提供实验依据,也有助于了解献血者的HCMV感染情况。方法:应用实时荧光定量PCR检测技术检测HCMV-DNA。结果:1037例血液样本HCMV测定的阳性率为3.66%(38/1037)。结论:对准献血人群进行HCMV测定,为临床安全输血提供实验依据,特别是对免疫功能低下或缺陷者、孕妇及新生儿的安全输血有重要的意义,同时也有助于了解献血者的HCMV感染情况。

Objective：To investigate the human cytomegalovirus （HCMV） infection status in prospective blood donors. Method：HCMV-DNA in blood samples collected from the prospective donors was detected using fluorescence quantitative real-time PCR （FQ-RT-PCR）. Result：In 1037 blood samples, the positive rate of HCMV-DNA was 3.66% （38 / 1037）. Conclusion：The risk of HCMV infection in patients who received blood transfusion donated by the prospective blood donors is relatively high. It seems that detection of HCMV in prospective blood do nots is very necessary for clinical blood transfusion safety, especially for those patients with low immune function or immune deficiency, as well as pregnant women and newborns. It is also helpful for understanding of HCMV in fection status of blood donors.