超敏C-反应蛋白与冠心病、心肌梗死的相关性探讨

Study on the correlation between hs-CRP and coronary heart disease as well as acute myocardial infarction

目的探讨血清超敏C-反应蛋白(hs-CRP)与冠心病(CHD)、心肌梗死(AMI)等疾病发生的关系。方法收集冠心病(CHD)患者61例、心肌梗死(AMI)患者45例作为患者组(排除同时引起的hs-CRP水平升高的其他疾病);收集肝肾功能、血脂、血糖、白细胞、心电图等体检指标正常的体检人员35例作为对照组。在日立7060全自动生化分析仪上应用乳胶增强免疫透射比浊法测定血清中hs-CRP的浓度和心肌酶谱,而心肌梗死组同时用免疫荧光法测定cTnI,并分析对照组与患者组、患者组治疗前后的hs-CRP水平的差异及hs-CRP与心肌酶谱、cTnI的关系。结果冠心病与心肌梗死患者的hs-CRP浓度与对照组相比明显升高,差异具有统计学意义(P<0.01);并且患者在治疗前后hs-CRP浓度差异有统计学意义(P<0.01)。而且hs-CRP与心肌酶谱、心肌肌钙蛋白(cTnI)的水平呈正相关关系。结论冠心病与心肌梗死患者血清hs-CRP水平明显升高。检测hs-CRP对冠心病与心肌梗死的辅助诊断、疗效观察及预后判断具有重要价值。

Objective To explore the relationship between high sensitivity C-reactive protein （hs-CRP） and the occurrence of certain diseases such as coronary heart disease （CHD） and acute myo cardial infarction （AMI）. Methods Sixty-one CHD patients, 45 AMI patients （patients group, excluding high hs CRP level diseases caused by other etiological factors） and 35 healthy controls （control group） were enrolled in the study. The serum level of hsCRP and myocardial zymogram was meas ured in the Hitachi 7060 automatic analyzer by latex-enhance immunoturbidimetry for all subjects, and cTnI of AMI group was detected with immunofluorescence method at the same time. The difference of hs CRP level was compared and analyzed between control group and patients group; control group be fore and after treatment. Moreover, the relationship between hs-CRP and myocardial zymogram as well as cTnI was analyzed. Results The level of hs CRP was significantly higher in patients group than that in control group （P〈0.01）. There was statistical difference of hs-CRP level before and after treatment in control group （P〈0.01）. hs-CRP was positively correlative with myocardial zymogram and cTnI. Conclusion The serum level of hs-CRP is significantly elevated in CHD and AMI patients, indicating the measurement of hs CRP contributes to auxiliary diagnosis, therapeutic effect observation, and prognosis evaluation.