大肠杆菌卷曲菌毛的生物合成和致病性

Biogenesis and Pathogenicity of Escherichia coli Curli Fibers

大肠杆菌卷曲菌毛是其菌体表面的一种含纤维素样蛋白质附着器官,出现在大肠杆菌生理和病理过程中。卷曲菌毛可以通过黏附等作用介导大肠杆菌侵袭宿主;作为一种细菌淀粉样蛋白,卷曲菌毛有可能引起淀粉样蛋白相关疾病;卷曲菌毛可以诱导宿主炎症因子水平升高,引起脓毒血症;卷曲菌毛可以和纤维素等一起构成菌外基质,参与生物膜的形成。我们简要综述了大肠杆菌卷曲菌毛的生物合成、生物学功能和致病性。

Escherichia coli curli are a kind of proteinaceous extracellular fibers, have been implicated in many physio-logical and pathogenic processes. E. coli curli fibers mediate the invasion of host cells by adhesion. As the bacterial amyloid, curli could cause amyloid associated diseases. Curli can induce and increase host＇s level of inflammatory factors, lead to sepsis. Curli and cellulose and other components constitute extracellular matrix of the cell, which are involved in biofilm forming. E.coli curli＇s biogenesis, physical functions and pathogenicity were reviewed as follows.