摘要
非编码RNA是一类没有开放阅读框、不能翻译成为蛋白质的RNA分子。在哺乳动物中,它们主要是指微小RNA、小干扰RNA、PIWI互作RNA和其他一些反义转录本等。它们在生物体内广泛存在,通过RNA干扰、基因沉默、基因印迹和DNA甲基化等机制调控着基因的表达。非编码RNA增加了真核细胞调控网络的复杂性,也为科学地解释一些现象提供了新的途径。
Non-coding RNAs are one class of RNA molecules including microRNA, small interfering RNA, PIWI-inter-acting RNA, and anti-sense transcripts. They can＇t be translated to proteins because they have no open reading frame.These non-coding RNAs widely spread in eukaryote and have the function of regulating gene expression by novel mechanisms such as RNA interference, gene silencing, imprinting and DNA methylation. Their existence greatly expands the complexity of regulatory net in eukaryote and provides some new ways to explain biologic process more accurately.
出处
《生物技术通讯》
CAS
2009年第1期89-93,共5页
Letters in Biotechnology
