治疗性血细胞单采及血浆置换在血液肿瘤疾病治疗中的应用研究

Clinical application of therapeutic hemapheresis and plasma exchange in hematology diseases

目的:观察血液肿瘤患者应用COBE Spectra血细胞分离机进行治疗性血液成分单采和血浆置换的临床疗效,分析影响其效果的相关因素。方法:对57例患者应用Spectra血细胞分离机进行69次治疗性血液成分单采和置换,分析临床效果和实验室指标的改善情况。结果:通过对急性白血病(AL)、慢性白血病(CL)、多发性骨髓瘤(MM)、血小板增多症(PV)等57例患者的治疗,血液成分单采和置换能快速、有效、选择性地减少患者血液中的病理性成分,促进临床症状和体征好转。结论:血细胞分离机进行治疗性血液成分单采和置换是临床上治疗血液系统疾患简洁而有效的辅助手段。

Objective：To investigate the clinical effect of therapeutic hemapheresis and plasma exchange by COBE Spectra for hematology diseases and analyze the correlate factors of affecting the hemapheresis. Methods： Hemapheresis and plasma exchange was done one to four times in 57 patients with hematology diseases（ acute leukemia,chronic leukemia, thrombo - cythemias, muhiple myelomas）. The clinical effect and laboratory index were analyzed. Results： After therapeutic hemocytes apheresis, symptoms and signs of patients were improved significantly, peripheral white blood cell counts, platelet counts, globulin of patients with leukemias, thrombocythemias and myelomas decreased. Condusion： Therapeutic hemapheresis is important for rapidly improving clinical symptoms and reduced occurrence of complications.