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镉致肾脏损伤的研究概况 被引量：7

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摘要 镉普遍存在于自然界,损害人体的多个系统。肾脏是对镉毒性最敏感也是最容易受损的器官。镉的毒性与细胞脂质过氧化密切相关。本文从镉诱导氧化损伤、氧化损伤与细胞凋亡、镉肾毒性的预防等方面对镉致肾损伤作用作一综述。
作者 马静 易建华
机构地区 西安交通大学医学院劳动卫生与环境卫生教研室
出处 《国外医学（卫生学分册）》 北大核心 2009年第1期34-37,共4页 Foreign Medical Sciences(Section of Hygiene)
关键词 镉 肾脏损伤 氧化应激 细胞凋亡 基因表达
分类号 R114 [医药卫生—卫生毒理学] R692 [医药卫生—泌尿科学]
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参考文献22

  • 1HORIGUCHI H, OGUMA E, KAYAMA F. Cadmium and cisplatin damage erythropoietin-producing proximal renal tubular cells[J] .Arch Toxicol,2006,80:680-686.
  • 2KOBAYASHI E, SUWAZONO Y, HONDA R, et al. Serial changes in urinary cadmium concentrations and degree of renal tubular injury after soil replacement in cadmium polluted rice paddies [ J ]. Toxicol Lett, 2008, 176 (2) : 124- 130.
  • 3HASWELL-ELKINS M, SATARUG S, ROURKE P O, et al. Striking association between urinary cadmium level and albuminuria among Tones Strait Islander people with diabetes[ J]. Environ Res, 2008,106 (3) : 379-383.
  • 4THIJSSEN S, LAMBRICHTS I, MARINGWA J, et al. Changes in expression of fibrotic markers and histopathologieal alterations in kidneys of mice chronically exposed to low and high Cd doses [J].Toxicology, 2007,238 (2-3) :200-210.
  • 5MAO W P, YE J L, GUAN Z B, et al. Cadmium induces apoptosis in human embryonic kidney (HEK) 293 cells by caspase-dependent and independent pathways acting on mitochondria[ J ]. Toxicol Vitro, 2007,21 (3) : 343-354.
  • 6OLABARRIETA I, L' AZOU B, YURIC S, et al. In vitro effects of cadmium on two different animal cell models[J].Toxicol Vitro,2001,15(4-5) :511-517.
  • 7CHARIER S, DOUKI T, CARREL C, et al. Cadmiuminduced oxidative stress and DNA damage in kidney of pregnant female rats[J]. Comptes Rendus Biologies, 2008, 331 (6) :426-432.
  • 8JOHANSEN P, MULVAD G, PEDERSEN H S, et al. Accumulation of cadmium in livers and kidneys in Greerdanders[ J ]. Sci Total Environ ,2006,372( 1 ) :58-63.
  • 9THIJSSEN S, CUYPERS A, MARINGWA J, et al. Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys [ J ]. Toxicology, 2007,236 ( 1-2 ) : 29-41.
  • 10GIAGINIS C, GATZIDOU E, THEOCHARIS S. DNA repair systems as targets of cadmium toxicity [J]. Toxieol Appl Pharmacol, 2006, 213(3):282-290.

二级参考文献23

  • 1任香梅,蔡云清,许冬青,王明艳,吴小丽.镉诱导猪肾近曲小管上皮细胞LLC-PK_1的凋亡[J].中国公共卫生,2004,20(6):720-721. 被引量：7
  • 2任香梅,蔡云清,吴小丽,陈渊华,吴静,黄晶晶.维生素C、维生素E、硒与镉联合作用对LLC-PK_1细胞脂质过氧化的影响[J].环境与职业医学,2004,21(4):295-298. 被引量：6
  • 3连祥霖.钼对汞毒性的保护作用[J].工业卫生与职业病,1995,21(3):149-150. 被引量：5
  • 4Yan H,Carter CE,Xu C,et al.Cadmium-induced apoptosis in the urogenital organs of the male rat and its suppression by chelation[J].J Toxicol Environ Health,1997,52(2):149-168.
  • 5Ishido M,Homma S,Leung P,et al.Cadmium-induced DNA fragmentation is inhibitable by zinc in porcine kidney LLC-PK1[ J ].Life-Sci,1995,56(17):351-356.
  • 6Kim MS,Kim BJ,Woo HN,et al.Cadmium induces caspase-mediated cell death:suppression by bcl-2[ J ].Toxicol,2000,145 (1):27-37.
  • 7Biagioli M,Watjen W,Beyersmann D,et al.Cadmium-induced apoptosis in murine fibroblasts is suppressed by bcl-2[ J ].Arch Toxicol,2001,75 (6):313-320.
  • 8Miyashita T,Krajewski S,Krajewska M,et al.Tumor suppressor p53 is a regulator of bcl-2 and bax in gene expression in vitro and in vivo[J].Oncogene,1994,9(6):1799-1805.
  • 9Scott H,Veronica P,Somji S,et al.Transient induction of metallothionein isform 3(MT-3),c-fos,c-jun,and c-myc in human proximal tubule cells exposed to cadmium[J ].Toxicol Lett,2002,126(1):69-80.
  • 10Ishido M,Tohyama C,Suzuki T.c-myc is not involved in cadmiumelicited apoptotic pathway in porcine kidney LLC-PK1 cells[ J ].Life-Sci,1998,63(14):1195-1204.

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二级引证文献23

国外医学（卫生学分册）
2009年 第1期

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