木丹颗粒治疗糖尿病性周围神经病变的作用机制

Treatment of diabetic peripheral neuropathy with Mudan granule

文中对木丹颗粒在组方原则、作用机制、疗效特点等方面进行了分析。该药物是通过调整影响神经代谢物质水平、修复受损神经、提高神经传导速度、解除机体疼痛症状、改善血液微循环等综合作用,延缓或逆转糖尿病周围神经病变(DPN)的发生和发展。同时笔者概述了木丹颗粒的研发背景及组方原则,列举了现用于DPN的辅助治疗药物,提出木丹颗粒为专门用于治疗DPN的新药,木丹颗粒早期介入治疗可延缓或阻止DPN的发生。

Based on basic and clinical research in the past 10 years as well as the theories of traditional Chinese medicine and modern Western medicine, we discussed prescription principles, preparation methods, mechanisms and efficacy of Mudan granule. It is effective in delaying or reversing the progress of diabetic peripheral neuropathy （DPN） through regulating neural metabolites, repairing injured nerves, increasing the speed of neural conductions, relieving pain and numbness, improving microcirculations and protecting organs from injuries with a better safety. It is an ideal drug for the clinical management of DPN patients. We also reviewed the research back- ground and prescription principles of Mudan granule, and listed current medications for DPN, which shows that early use of Mudan granule is a new medication for DPN.