离子交换树脂在口服液体制剂矫味中的应用

Application of ion exchange resins as taste-masked agents in liquid oral formulations

改善口感和掩盖苦味是口服液体制剂的一个重要研究课题。离子交换树脂是一类能进行离子交换的功能性高分子聚合物,与药物结合形成药物树脂复合物之后,可以改善或屏蔽药物的苦味。国内外已上市的多种产品使用了离子交换树脂作为药用矫味剂。文中简要介绍了离子交换树脂的种类、基本性质、作用原理以及在口服液体制剂矫味中的作用机制、独特优势和应用研究进展。

The key issue of functional polymer that can cover up liq bit uid oral formulations is to improve the bitter taste. Ion exchange resin is a terness via combining drug to form drug-resin complex and exchanging ions In many medicinal products, ion exchange resins are used as duced the character, species, actions, mechanisms, and its taste-masked agents excellent properties In this article, of ion exchange we briefly introresins in liquid oral formulations as a taste-masked agent.