我院120例药品不良反应报告分析

ADR Reports:Analysis of 120 Cases in Our Hospital

目的:分析我院药品不良反应(ADR)发生的特点与一般规律,促进临床合理用药。方法:采用回顾性方法,对我院2007年1～6月上报的120份ADR报告,按患者年龄、性别、给药途径、引起ADR的药品种类、涉及器官或系统以及临床表现等进行统计、分析。结果:静脉给药较其他给药途径更易发生ADR(占68.3%);抗感染药物引发ADR的比例最高(占46.7%),其次为神经系统与心血管系统药物;氟喹诺酮类是引发ADR的主要抗感染药(19例,占33.9%),其中又以左氧氟沙星为首。ADR的临床表现以皮疹、瘙痒等皮肤及附件损害为主,其次为消化系统以及循环系统损害。结论:应强化ADR监测意识,完善相关报告分析制度,确保临床安全、有效、合理用药。

OBJECTIVE： To analyze the characteristics and regularity of the adverse drug reaction （ADR） occurred in our hospital so as to promote rational drug use. METHODS： By a retrospective study, a total of 120 ADR case reports collected from our hospital from Jan. to June in 2007 were subjected to a statistical analysis in respect of patients＇ age and sex, route of administration, drug categories inducing ADRs, the organs or system involved and the clinical manifestations etc. RESULTS： Of the total 120 ADR cases, 68.3 % were induced by intravenous administration, and 46.7 % were induced by anti-infective drugs, followed by drugs used for nervous system and cardiovascular disease. Quinolones were the major anti-infective drugs, which caused ADR in 19 cases （33.9%）, of all the quinolones used, levofloxacin took the lead. The ADRs manifested dominantly by skin rash and pruritus followed by lesions of digestive system and circulatory system. CONCLUSION： ADR monitoring should be strengthened and the related ADR reporting and analyzing system should be evolved to ensure clinical safe, effective and rational use of drugs.