脑钠肽检测对急性冠脉综合征患者的诊断意义

Clinical meaning of brain natriuretic peptide in diagnosing the patients with acute coronary syndrome

目的:探讨急性冠脉综合征患者血浆脑钠肽(BNP)浓度的变化及其临床意义。方法:选取健康体检者20例,稳定型心绞痛(SAP)患者15例,急性冠脉综合征(ACS)患者45例,其中ACS组再分为不稳定型心绞痛(UA)组20例和急性心肌梗死(AMI)组25例,采用干式快速免疫荧光法分别测定其脑钠肽浓度。结果:与健康对照组的(49.40±15.10)pg/ml和稳定型心绞痛(SAP)组的(56.39±36.50)pg/ml比较,ACS组血浆BNP浓度明显升高(P<0.05;P<0.05;P<0.01;P<0.05),且心肌梗死(AMI)亚组BNP浓度(587.57±205.65)pg/ml高于不稳定心绞痛(UA)亚组(356.17±150.26)pg/ml(P<0.01),SAP组和对照组BNP浓度差异无统计学意义(P>0.05)。结论:ACS患者血浆BNP浓度明显升高,心肌梗死患者较不稳定型心绞痛患者更为显著。故血浆BNP检测可为急性冠脉综合征诊断提供非常有价值的参考依据。

Objective： To explore the variation and clinical meaning of brain natriuretic peptide in patients with acute coronary syndrome（ACS）. Methods： Plasma BNP in 20 healthy, 15 SAP patients and 45 ACS patients was tested by fluoroimmunoassay.ACS patients were divided into unstable angina peetoris （UA） group and myocardial infarction（AMI） group. Results： Compared to healthy group（49.40±15.10） pg/ml and SAP group（56.39±36.50） pg/ml, the plasma BNP level in ACS group was significantly higher（P〈0.05,P〈0.05;P〈0.01;P〈0.05）.The plasma BNP level in AMI group（587.57±205.65） pg/ml was significantly higher than that in UAP group （356.17±150.26） pg/ml （P〈0.01）.But there was no significant difference between SAP level in AMI group and control group （P〉0.05）. Conclusion： Plasma BNP level increased significantly in patients with ACS. It seems more prominent in patients with AMI. Plasma BNP can be used as a diagnostic parameter for acute coronary syndrome.