头孢西丁钠的合成

Synthesis of Cefoxitin Sodium

头孢西丁是一种具有长效、广谱抗菌特点的第二代头孢类抗生素。本文以头孢噻吩酸为原料,甲氧基化产物不需结晶提纯而直接用于去乙酰化,缩短了生产周期和节省了原料。本方法制备简便,适于工业化生产。

Cefoxitin, the second -generation cephalosporins, is permanence and has a broad spectrum of antibacterial activity . In this paper, starting from cephalotin, the cefoxitin was obtained via 3 steps including methoxylation, deacetylation and carbamoylation. The poduct of methoxylation could be used for deacetylation without crystallition and purification, and the materials were redused and production cycle was shorten. The method is simple and convenient and can be scaled up to indusrtrial production.