TP和ES在胃癌组织中的表达及其意义

Expressions of TP and ES in the patients with gastric cancer and its clinical significance

目的:胸腺嘧啶磷酸化酶(TP)和血管内皮抑素(ES)在胃癌组织中的表达对判断预后与治疗的选择有着积极意义,我们对TP和DS在胃癌与癌旁正常组织中的表达进行了研究,以评估其潜在的临床意义。方法:应用ELISA方法对52例胃癌患者癌组织和癌旁正常组织TP和ES的含量进行检测并行统计学分析。结果:52例患者中,癌组织TP平均浓度为(144.51±13.52)ng/mg,ES平均浓度为(42.36±11.36)ng/mg。癌旁正常组织TP平均浓度为(15.84±3.14)ng/mg,ES平均浓度为(38.25±8.65)ng/mg。癌组织中TP浓度比正常组织高近10倍(P<0.01)。结论:胃癌组织中TP的表达远高于癌旁正常组织,ES的表达在癌组织和癌旁正常组织中无显著差异,癌组织中TP与ES的比值远高于癌旁正常组织。

Objective The expressions of Thymidine phosphory （TP） and Endostatin （ES） in gastric cancer tissue has significant values in terms of prognosis and treatment choice for the patients. The aim of the present study was to investigate the expression of TP and ES in both gastric tissues and normal gastric tissues, and to determine its potential clinical significance. Method TP and ES expressions in 52 pairs of gastric cancer tissues and normal gastric tissues were measured by ELISA. Results In gastric cancer tissues, the average level of TP and KS were （ 144.51 ± 13.52） ng/mg and （42.36 ±11.36） ng/mg; in normal tissues, it was （ 15.84 ±3.14） ng/mg and （38.25 ±8.65） ng/mg. The level of TP in gastric cancer tissues was almost 10 times higher of that in normal tissues. Conclusion The expression of TP is much higher in gastric cancer tissue than in normal tissue, while there is no significant difference between cancer tissue and normal tissue in term of ES expression, the ratio of TP to ES is much higher in gastric cancer tissue.