二甲基叔丁基-(4-甲基-4-烯戊氧基)硅烷的合成及表征

Synthesis and characterization of tert-butyl-dimethyl-(4-methyl-pent-4-enyloxy)-silane

首先以四氢呋喃为溶剂对3-氯-2-甲基丙烯进行格氏反应,制备出的格氏试剂再进一步与环氧乙烷反应其产物为4-甲基-4-戊烯醇,而后用叔丁基二甲基氯硅烷对上述产物4-甲基-4-戊烯醇上的羟基进行保护,制备出标题化合物。随后分别对4-甲基-4-戊烯醇以及标题化合物进行红外及核磁共振检测,所得到的检测谱图证实产物与目标分子的结构相吻合,并讨论了格氏试剂溶剂的选取对反应的影响。

The Grignard reagent was prepared by the reaction of 3-chloro-2-methlpropene with Mg. Then 4-methyl-pent-4-en-1-ol was synthesized by the reaction of the Grignard reagent with ethylene oxide, and then the reaction product reacted with tertbutyldimethysilyl chloride. The product was confirmed by FT-IR and ^13CNMR spectrometry. The influence of the solvent for the Grignard reagent on the reaction was discussed.