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新手性试剂(1R，2S)-2-氨基醇的合成

Synthesis of novel (1R,2S)-2-aminoalcohols
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摘要 采用格氏试剂C6H13MgBr和C10H7MgBr对光学活性O-TMS保护的(R)-氰醇的氰基加成,随之用NaBH4对亚胺化合物立体诱导还原氢化,以>98%的de值合成了两个新的手性试剂(1R,2S)-2-氨基醇,产率分别达到59%和62%,并通过X射线单晶结构分析法测定了分子结构和晶体结构。 The reactions for addition of two kinds of Gfignard reagents C6H13MgBr and C10H7MgBr to the CN group of optically active O-TMS protected （ R）-cyanohydrin, followed by reduction of imine compounds by NaBH4, were studied. Two kinds of （1 R, 2S）-2-aminoalcohols with 〉 98% de value were synthesized. The yields were 59 % and 62 %, respectively. The crystal structure was determined by the X-ray diffraction method.
作者 褚朝森 韩世清
机构地区 南京工业大学制药与生命科学学院 连云港中医药高等职业技术学校
出处 《化学试剂》 CAS CSCD 北大核心 2009年第2期125-127,130,共4页 Chemical Reagents
关键词 氨基醇 醇腈裂解酶 不对称合成 aminoalcohol oxynitrilase asymmetric synthesis
分类号 TQ226.62 [化学工程—有机化工]
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参考文献13

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二级参考文献9

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化学试剂
2009年 第2期

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