摘要
目的研究4种不同配比的头孢噻肟钠/他唑巴坦钠(CTX/TAZ)(2:1、4:1、6:1、8:1)及头孢噻肟钠(CTX)单剂对四川地区临床分离致病菌的体外抗菌作用。方法采用平皿二倍稀释法测定465株临床分离致病菌的最低抑菌浓度(MIC)。结果联合配伍可以使金黄色葡萄球菌(MRSA)、表皮葡萄球菌(MSSE和MRSE)、粪肠球菌、大肠埃希菌(产ESBLs)、铜绿假单胞菌、阴沟肠杆菌、肺炎克雷伯菌(产ESBLs)和鲍曼不动杆菌等从CTX单用的MIC50值128~>256mg·mL-1降至2~64mg.L-1,下降幅度达4~128倍。结论不同配比的CTX/TAZ均有强大的杀菌作用,明显优于CTX单剂。6:1的CTX/TAZ复方制剂为较合理的配方组合,具有进一步的研究开发价值。
OBJECTIVE To study the antibacterial activities of cefotaxime (CTX) and different ratios from matching cefotaxime/ tazobactam(CTX/TAZ) (2 : 1,4 : 1,6 : 1 ,8 : 1 ) against clinically isolated pathogenic bacteria from Sichuan area in vitro. METH- ODS Minimal inhibitory concentrations (MIC) were determined by use of agar dilution method on 465 clinically isolated pathogenic bacteria. RESULTS MICs0 of CTX/TAZ with different ratios against Staphylococcus anreus ( MRSA), Staphylococcus epidermidis (MSSE and MRSE) , Enterococcus faecalis, Escherichia coli (ESBLs ~ ) , Pseudomonas aeruginosa, Aerobacter cloacae, Klebsiella pneumoniae( ESBLs + ) and Baumanii were 2 -64 mg L-1 , which was 4 - 128 times lower than that of CTX alone. CONCLUSION Different formulas of CTX/TAZ (2 : 1,4 : 1,6 : 1, 8 : 1 ) showed higher antibacterial activity against most clinical isolates than CTX alone in vitro. CTX/TAZ 6 : 1 is a better formulation and valuable to be investigated.
出处
《华西药学杂志》
CAS
CSCD
北大核心
2009年第1期38-41,共4页
West China Journal of Pharmaceutical Sciences
关键词
头孢噻肟钠/他唑巴坦钠
体外抗菌作用
Cefotaxime/Tazobactam (CTX/TAZ)
In vitro antibacterial activity