期刊文献+

2-甲氧基-6-(2′-萘基)丙酸-(2,″2″-二甲基-3″-溴)丙酯水解反应制备萘普生 被引量:2

Preparation of Naproxen by Hydrolysis of 2-Methoxy-6(2′-naphthyl) propionic acid 2″-2″dimethyl-3″-bromo)propyl Ester
下载PDF
导出
摘要 用氢氧化钠水溶液水解2-甲氧基-6-(2′-萘基)丙酸=(2″,2″-二甲基-3″-溴)丙酯得到萘普生,以萘普生收率为主要指标,用均匀设计和单因素实验方法,考察了NaOH质量分数,物料摩尔比,水解时间对水解反应的影响。结果表明:在水解温度(110±5)℃,水解反应时间60~90min,W(NaOH)=40%,n(氢氧化钠):n(原料)=4.4:1的条件下,萘普生收率可达99.19%。同时确定了高效液相色谱分析萘普生的分析方法。 2-Methoxy-6-( 2'-naphthyl ) propionic acid-( 2″, 2″-dimethyl-3″-bromo ) propyl ester was hydrolyzed to naproxen by sodium hydroxide. In order to get the optimal condition, this study use uniform design and the single factor experiment based on the yield of naproxen. The main factors which affect the hydrolysis, such as the mass fraction of sodium hydroxide, materials molar ratio and the reaction time were studied in detail. Results indicated that the yield of naproxen could reach 99. 19% under the optimal conditions of the hydrolysis temperature of ( 110 ± 5 ) ℃, the reaction time between 60 and 90 min, the mass fraction of sodium hydroxide of 40% and the materials ratio of 4. 4 : 1. A method for analyzing the amount of naporoxen in the reactant by HPLC was developed.
出处 《精细化工》 EI CAS CSCD 北大核心 2009年第2期170-172,201,共4页 Fine Chemicals
基金 河南省自然科学基金资助项目(No.0211020800)~~
关键词 2-甲氧基-6-(2′-萘基)丙酸=(2″ 2″-二甲基-3″-溴)丙酯 萘普生 水解反应 2-methoxy-6-( 2'-naphthyl ) propionic acid-( 2″, 2″-dimethyl-3″-bromo) propyl ester naproxen hydrolysis
  • 相关文献

参考文献10

二级参考文献22

共引文献35

同被引文献47

  • 1辛嘉英,于佳琪,李海燕,王艳,夏春谷.脂肪酶催化二次动力学拆分制备高光学纯度(S)-萘普生[J].分子催化,2015,29(1):90-95. 被引量:9
  • 2Claudio Babiloniab,*,Giovanni B.Frisonic,Claudio Del Pereioc et al.Ibuprofen treatment modifies cortical sources of EEG rhythms in mild Alzheimer's disease[J].Clinical Neurophysiology,(2009)709-718.
  • 3William M,Bennett,William L.Henrich,Jeffrey S.Stoff.The renal effects of non-steroidal anti-inflammatory drugs:Sununary and recommendations[J].American Journal of Kidney Diseases,1996,28(1):S56-S62.
  • 4Gimewo Navarro A,Cano Sanchez A,Fernandez Gilino C,et al.Ibuprofen versus indomethacin in the treatment of patent ductus arterious in preterm infants[J].An prdiatr,2005,63(3):212-218.
  • 5Angel Lanas,Federico Sopena.Nonsteroidal Anti-Inflammatory Drugs and Lower Gastrointestinal Complications[J].Gastroenterology Clinics of North America,2009,38(2):333-352.
  • 6FDA Approves Injectable Form of Ibuprofen http://www.fda.gov/NewsEvents.
  • 7Yilmaz E, Sezgin M, Yilmaz M. Enantioselective hydrolysis of rasemic naproxen methyl ester with sol-gel encapsulated li- pase in the presence of sporopollenin[J]. J Mol Catal B En- zym, 2010,62(2):162-168.
  • 8Morrone R, D'Antona N, Lambusta D. Biocatalyzed irrevers- ible esterification in the preparation of S-naproxen[J]. J Mol Catal B Enzym, 2010,65(1/4):49-51.
  • 9Takac S, Unlu A E. Effects of alcohol and buffer treatments on the activity and enantioselectivity of Candida rugosa lipase [J]. Prep Biochem Biotechnol, 2009,39(2):124-141.
  • 10Cai X Q, Wang N, Lin X F. The preparation of polymeriz- able, optically active non-steroidal anti-inflammatory drugs de- rivatives by irreversible enzymatic methods[J]. J Mol Catal B Enzym, 2006,40(1/2):51-57.

引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部