2,4-二氯-5-羟基苯肼的制备

Preparation of 2, 4-dichloro-5-hydroxy-phenylhydrazine

文章选择以2,4-二氯苯酚为起始原料,经羟基保护、硝化、水解、还原、重氮化、还原,成功合成了2,4-二氯-5-羟基苯肼,优化实验条件下六步反应总摩尔收率可达46.6%(以2,4-二氯苯酚计)。产品熔点与文献相符,又经元素分析、红外光谱、核磁共振波谱表征了其结构。

In the paper, various synthetic routes to obtain 2,4-dichloro-5-hydroxyphenylhydrazine were briefly discussed. 2,4-dicholorophenol was chosen as starting material, followed by esterification, natration, hydrolyzation, reduction, diazotization, reduction, the products were obtained. The products were characterized by melting point measurement, fourier transform infrared （FT-IR） and hydrogen nuclear magnetic resonance （H^1-NMR）. The melting point of the products was identical with the literature, and the stucture was also confirmed by FT-IR and H-NMR. Throush optimizing the experimental parameters, the molar yields of the final products could reach as high as 46.6 %.