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盐酸度洛西汀合成工艺改进

Improved Synthesis of Duloxetine Hydrochloride
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摘要 目的合成盐酸度洛西汀并改进合成工艺。方法以3-氯-1-(2-噻吩基)丙酮-1为起始原料,经还原、碘代、氨化、拆分、醚化、成盐等反应制得盐酸度洛西汀。结果所得产物经元素分析、红外光谱、核磁共振氢谱及质谱等确证了结构。结论改进工艺路线方法简便,原料易得,便于工业化生产。 Objective To synthesize duloxetine hydrochloride and to optimize the process. Methods Duloxetine hydrochloride was synthesized by steps of reaction （reduction, iodination, ammoniation, resolution, etherification and salification） from 1 - （2 -thienyl） -3 -chloropropan- 1-one. Results The chemical structure of duloxetine hydrochloride was confirmed by element analysis, IR, 1H-NMR, and ESIMS. Conclusion This process can be easily controlled and is suitable for a large scale production.
作者 肖健
机构地区 福建卫生职业技术学院
出处 《中国药业》 CAS 2009年第4期23-24,共2页 China Pharmaceuticals
关键词 盐酸度洛西汀 抗抑郁药 合成 duloxetine hydrochloride antidepressant drug synthesis
分类号 R914.2 [医药卫生—药物化学] R971.43 [医药卫生—药品]
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参考文献6

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二级参考文献44

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中国药业
2009年 第4期

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