摘要
目的合成盐酸度洛西汀并改进合成工艺。方法以3-氯-1-(2-噻吩基)丙酮-1为起始原料,经还原、碘代、氨化、拆分、醚化、成盐等反应制得盐酸度洛西汀。结果所得产物经元素分析、红外光谱、核磁共振氢谱及质谱等确证了结构。结论改进工艺路线方法简便,原料易得,便于工业化生产。
Objective To synthesize duloxetine hydrochloride and to optimize the process. Methods Duloxetine hydrochloride was synthesized by steps of reaction (reduction, iodination, ammoniation, resolution, etherification and salification) from 1 - (2 -thienyl) -3 -chloropropan- 1-one. Results The chemical structure of duloxetine hydrochloride was confirmed by element analysis, IR, 1H-NMR, and ESIMS. Conclusion This process can be easily controlled and is suitable for a large scale production.
出处
《中国药业》
CAS
2009年第4期23-24,共2页
China Pharmaceuticals
关键词
盐酸度洛西汀
抗抑郁药
合成
duloxetine hydrochloride
antidepressant drug
synthesis