莫西沙星短程疗法对65岁以上AECOPD的近、远期疗效及安全性评价

Evaluation of short-term and long-term efficacy and safety of short-course therapy of moxifloxacin in treating senile patients with AECOPD

目的评价莫西沙星短程疗法对65岁以上AECOPD的疗效和安全性。方法60例AECOPD(年龄≥65岁)随机分为两组,试验组(30例)给予莫西沙星0.4静滴,1次/d,疗程5d,对照组(30例)给予头孢哌酮舒巴坦3.0静滴,2次/d,和阿齐霉素0.5静滴,1次/d,疗程10天。结果治疗结束时试验组和对照组的临床有效率分别为93.33%和70.00%(P<0.05),细菌学清除率分别为90.91%和75.00%(P>0.05);试验组和对照组不良反应发生率分别为10.00%和6.67%(P>0.05)。结论莫西沙星短程疗法治疗AECOPD不仅起效快,近期疗效好,而且可以延长至下次急性发作时间的间期,减少1年内急性发作次数和使用其他抗生素的频率,可以作为AECOPD的一线治疗方案,在老年病人可安全使用。

Objective To evaluate the efficacy and safety of short-course therapy of moxifloxacin in treating senile patients with AECOPD. Methods 60 senile patients with AECOPD were randomly divided into 2 groups. 30 cases of trial group were given intravenous moxifloxacin （0. 4 qd ×5 d） , 30 cases of control group were given intravenous cefperazone-sulbactam （3.0 bid × 10 d） and intravenous azithromycin （0. 5 qd × 10 d）. Results The total clinical efficacy rate was 93.33% in the trial group and 70. 00% in the control group （P 〈 0.05 ）, bacterial eradication rate was 90. 91% and 75.00%, respectively （P 〉 0. 05 ）. The incidence of adverse drug reaction was 10. 00% and 6.67%, respectively （ P 〉 0. 05 ）. Conclusion Short-course therapy of moxifloxacin shows good short-and long-term efficacy in the trentment of AECOPD. It is also safe in the senile patients and should be regarded as one of the first choice in treating AECOPD.