固尔苏预防新生儿呼吸窘迫综合征的疗效分析

The study of Curosurf in preventing respiratory distress syndrome of newborns

目的探讨固尔苏(肺泡表面活性物质制剂)预防新生儿呼吸窘迫综合征的疗效。方法将45例同条件早产儿分为两组,观察组21例于生后2h内经气管注入固尔苏;对照组24例未使用固尔苏,比较两组早产儿呼吸窘迫综合征发生率、需要呼吸机治疗的比例、常见并发症的发生率及预后。结果观察组早产儿呼吸窘迫综合征发生率、需要呼吸机治疗的比例及常见并发症的发生率均较对照组减低(P<0.05)。结论高危早产儿生后应尽早预防性使用固尔苏,可有效降低呼吸窘迫综合征的发病率,减少并发症的发生和呼吸机的应用,提高早产儿生存质量。

Objective To evaluate the effect of Curosurf （pulmonary surfactant） in preventing respiratory distress syndrome of newborns. Methods Forty-five pretcrm infants with same condition were randomly divided into two groups. Twenty-one neonates of treated group were dripped in Curosurf through trachea within two hour after birth and twenty-four neonates served as the control group didn＇t get Curesurf. The morbidity of respiratory distress syndrome（RDS） ,cases needed mechanical ventilation,the common complications and the prognosis were compared between the two groups. Results The incidences of RDS,complications and cases needed mechanical ventilation in treated group were obviously lower than those in control group （ P 〈 0. 05 ）. Conclusion The preventive application of Curosurf early for high-risk premature infants can effectively reduce the incidences of RDS,the common complications and the eases needed mechanical ventilation , then improve the quality of life in preterm infants.