支气管哮喘与NO浓度的检测研究及临床意义

The research and clinic meaning of asthma and detection about no concentration

目的检测支气管哮喘患者在症状急性发作时经口腔呼出气中NO浓度及血浆中NO的浓度,研究NO浓度与哮喘严重程度和治疗效果的关系。方法选择支气管哮喘急性期发作患者30例,测定在急性发作期呼出气体中NO浓度、血浆中NO浓度;经过舒利迭吸入治疗,一吸,一日两次,治疗1个月后再次分别测定NO的浓度。结果支气管哮喘症状急性发作期组患者呼出气以及血浆中NO浓度均明显高于缓解期和正常对照组。结论呼出气体中NO浓度以及血浆中NO的检测为临床哮喘的诊断及治疗效果的判断提供参考。

Objective To detect the fractional concentration of the both exhaled and serium niricoxide in asthmtic patients and in normal people, and after a month of drug therapy, detect the data again. We study the relationship between nirieoxide concentration and asthmatic therapy and the severity of the asthma. Methods We ehoose 30 asthmatic patients and all of them have no other respiratory disease. When the patients are onset, we detected the fractional concentration of the both exhaled and serum niricoxide; after a month of therapy with Seretide （Salmeterol 50 μg ＋ Fluticasone 500 μg） one puff, twice per day, the patients asthmatic symptom were released, and we detect the no concentration again. Results The no concentration was obviously high in asthmatic onset patients than in both symptomatic relief patients and normal people. Conclusion The detection of the fractional concentration of the exhaled and serium niricoxide can offer reference for the asthma diagnosis and the evaluation of the therapy.