5-氨基酮戊酸光动力疗法治疗痤疮

Topical aminolevulinic acid-photodynamie therapy in aene

目的探索5-氨基酮戊酸光动力疗法（ALA—PDT）治疗中、重度痤疮的安全性及有效性。方法将70例中、重度痤疮患者随机分为两组。治疗组35例，给予ALA—PDT治疗，每2周治疗1次，共治疗1～3次；对照组35例，口服异维A酸胶囊治疗，共服用6周。在治疗第2、4、6周对两组患者进行疗效判断和比较。结果35例接受ALA—PDT治疗的患者经过1～3次治疗后（第2、4、6周），总有效率达97．1％；对照组于6周时总有效率为80．0％，治疗组疗效明显优于对照组（P〈0．05）。另外，AIJA—PDT组复发程度明显轻于对照组，且病情控制时间明显延长。ALA—PDT组有个别患者局部出现暂时性色素沉着，但无瘢痕发生。结论ALA—PDT是一种简单、高效、不良反应轻微的治疗中、重度痤疮的新疗法。

Objective To investigate the effect and safety of photodynamic therapy （PDT） with topical aminolevulinic acid （ALA） in moderate to severe ache. Methods Seventy patients with moderate to severe acne were randomly divided into two groups, one group was treated with topical ALA-PDT for 1-3 sessions with an interval of 2 weeks, the other group received oral isotretinoin 10 mg twice a day for 6 weeks. Patients were evaluated for efficacy on week 2, 4 and 6 after the initial treatment. A 3-month follow up was performed to monitor adverse events following the end treatment. Results The total effective rate was 97.1% in ALA-PDT group after 1-3 sessions of treatment, 80.0% in the control group on week 6, and the difference was significant between the two groups （P 〈 0.05 ）. Acne lesions tended to recur more slightly with a longer remission period in ALA-PDT group than in the control group. A temporary and local pigmentation was observed in some patients treated with ALA-PDT, but no scar was noticed. Conclusion Topical ALA-PDT is a simple and effective treatment option for moderate to severe acne with mild side effects.