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皮肤鳞状细胞癌组织中CD147、MMP-9及TIMP-2蛋白的表达 被引量：2

Expression of CD147,MMP-9 and TIMP-2 in cutaneous squamous cell carcinoma tissue
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摘要 目的:检测皮肤鳞状细胞癌(SCC)组织中细胞外基质金属蛋白酶诱导因子(CD147)、基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶抑制剂-2(TIMP-2)蛋白的表达。方法:采用免疫组织化学SP法检测51例SCC,17例正常皮肤组织石蜡标本中CD147,MMP-9及TIMP-2蛋白的表达。结果:SCC组织中CD147,MMP-9蛋白的阳性表达率(65%和59%)明显高于正常皮肤(12%和18%,P<0.05),TIMP-2(37%)明显低于正常皮肤(76%,P<0.05)。SCC组织中CD147的阳性表达率与MMP-9的阳性表达率呈正相关(r=0.466,P<0.05),与TIMP-2的阳性表达率呈负相关(r=-0.427,P<0.05)。结论:在SCC的发生过程中CD147,MMP-9和TIMP-2起一定作用。 Aim： To detect the expression of extracellular matrix metalloprotease inducer（CD147） ,matrix metalloproteinase-9 （MMP-9） and tissue inhibitor of metalloprotease-2 （TIMP-2） in cutaneous squamous cell carcinoma （SCC） tissue. Methods：The expressions of CD147, MMP-9 and TIMP-2 were detected in 51 cases of SCC tissue and 17 cases of normal skin tissue by immunohistochemieal SP. Results： The positive expression rates of CD147 and MMP-9 in SCC were higher than those in normal skin tissue （P 〈 0.05） , respectively, while the positive expression rates of TIMP-2 was lower （ P 〈 0.05 ）. The expression of CD147 in SCC tissue was postively correlated with that of MMP-9 （ r = 0. 466, P 〈 0.05 ）, and negatively correlated with that of TIMP-2 （ r = - 0. 427, P 〈 0.05 ）. Conclusion ： It is suggested that expression of CD147, MMP-9 and TIMP-2 may be closely correlated with generation of SCC.
作者 陈旻静 武海龙
机构地区 郑州大学第一附属医院整形外科 洛阳市中心医院烧伤整形科
出处 《郑州大学学报（医学版）》 CAS 北大核心 2009年第1期110-112,共3页 Journal of Zhengzhou University(Medical Sciences)
关键词 皮肤肿瘤 鳞状细胞癌 细胞外基质金属蛋白酶诱导因子 基质金属蛋白酶-9 基质金属蛋白酶抑制剂-2 cutaneous neoplasm squamous cell carcinoma extracellular matrix metalloprotease inducer matrix metalloproteinase-9 tissue inhibitor of metalloprotease-2
分类号 R739.5 [医药卫生—肿瘤]
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参考文献8

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同被引文献19

  • 1Clara Luz Sampieri,Sol de la Pea,Mariana Ochoa-Lara,Roberto Zenteno-Cuevas,Kenneth León-Córdoba.Expression of matrix metalloproteinases 2 and 9 in human gastric cancer and superficial gastritis[J].World Journal of Gastroenterology,2010,16(12):1500-1505. 被引量：46
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郑州大学学报（医学版）
2009年 第1期

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